WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122930
CAS#: 574759-62-9
Description: VAF347 is an agonist of the aryl hydrocarbon receptor (AhR).
Hodoodo Cat#: H122930
Name: VAF347
CAS#: 574759-62-9
Chemical Formula: C17H11ClF3N3
Exact Mass: 349.06
Molecular Weight: 349.740
Elemental Analysis: C, 58.38; H, 3.17; Cl, 10.14; F, 16.30; N, 12.01
Synonym: VAF347; VAF 347; VAF-347
IUPAC/Chemical Name: 4-(3-chlorophenyl)-N-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine
InChi Key: XTKUZTBZRIJTFR-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H11ClF3N3/c18-13-3-1-2-11(10-13)15-8-9-22-16(24-15)23-14-6-4-12(5-7-14)17(19,20)21/h1-10H,(H,22,23,24)
SMILES Code: FC(C1=CC=C(C=C1)NC2=NC=CC(C3=CC(Cl)=CC=C3)=N2)(F)F
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 349.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zapadka TE, Lindstrom SI, Batoki JC, Lee CA, Taylor BE, Howell SJ, Taylor PR.
Aryl Hydrocarbon Receptor Agonist VAF347 Impedes Retinal Pathogenesis in
Diabetic Mice. Int J Mol Sci. 2021 Apr 21;22(9):4335. doi: 10.3390/ijms22094335.
PMID: 33919327; PMCID: PMC8122442.
2: Ibabao CN, Bunaciu RP, Schaefer DM, Yen A. The AhR agonist VAF347 augments
retinoic acid-induced differentiation in leukemia cells. FEBS Open Bio. 2015 Apr
8;5:308-18. doi: 10.1016/j.fob.2015.04.002. PMID: 25941627; PMCID: PMC4412882.
3: Baba N, Rubio M, Kenins L, Regairaz C, Woisetschlager M, Carballido JM,
Sarfati M. The aryl hydrocarbon receptor (AhR) ligand VAF347 selectively acts on
monocytes and naïve CD4(+) Th cells to promote the development of
IL-22-secreting Th cells. Hum Immunol. 2012 Aug;73(8):795-800. doi:
10.1016/j.humimm.2012.05.002. Epub 2012 May 17. PMID: 22609446.
4: Lawrence BP, Denison MS, Novak H, Vorderstrasse BA, Harrer N, Neruda W,
Reichel C, Woisetschläger M. Activation of the aryl hydrocarbon receptor is
essential for mediating the anti-inflammatory effects of a novel low-molecular-
weight compound. Blood. 2008 Aug 15;112(4):1158-65. doi:
10.1182/blood-2007-08-109645. Epub 2008 Feb 12. PMID: 18270326; PMCID:
PMC2515129.
5: Platzer B, Richter S, Kneidinger D, Waltenberger D, Woisetschläger M, Strobl
H. Aryl hydrocarbon receptor activation inhibits in vitro differentiation of
human monocytes and Langerhans dendritic cells. J Immunol. 2009 Jul
1;183(1):66-74. doi: 10.4049/jimmunol.0802997. Epub 2009 Jun 17. PMID: 19535631.