WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130308
CAS#: N/A
Description: S1-Puro is the prodrug of puromycin, activated by selenoprotein thioredoxin reductase (TrxR), reducing off-site cytotoxicity. Puromycin inhibits protein synthesis by prematurely causing termination of chain elongation during translation, to be used for treatment of cancers where TrxR is overexpressed.
Hodoodo Cat#: H130308
Name: S1-Puro
CAS#: N/A
Chemical Formula: C26H33N7O7S2
Exact Mass: 619.19
Molecular Weight: 619.710
Elemental Analysis: C, 50.39; H, 5.37; N, 15.82; O, 18.07; S, 10.35
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: S1-Puro; S1 Puro
IUPAC/Chemical Name: 1,2-dithiolan-4-yl ((S)-1-(((2S,3S,4R,5R)-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)amino)-3-(4-methoxyphenyl)-1-oxopropan-2-yl)carbamate
InChi Key: AOYMQWSDCOEVCI-OFHCFCQESA-N
InChi Code: InChI=1S/C26H33N7O7S2/c1-32(2)22-20-23(28-12-27-22)33(13-29-20)25-21(35)19(18(9-34)40-25)31-24(36)17(8-14-4-6-15(38-3)7-5-14)30-26(37)39-16-10-41-42-11-16/h4-7,12-13,16-19,21,25,34-35H,8-11H2,1-3H3,(H,30,37)(H,31,36)/t17-,18+,19+,21+,25+/m0/s1
SMILES Code: O=C(OC1CSSC1)N[C@@H](CC2=CC=C(OC)C=C2)C(N[C@@H]3[C@@H](CO)O[C@@H](N4C=NC5=C(N(C)C)N=CN=C45)[C@@H]3O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 619.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Chang B, Xu Q, Guo H, Zhong M, Shen R, Zhao L, Zhao J, Ma T, Chu Y, Zhang J, Fang J. Puromycin Prodrug Activation by Thioredoxin Reductase Overcomes Its Promiscuous Cytotoxicity. J Med Chem. 2023 Mar 9;66(5):3250-3261. doi: 10.1021/acs.jmedchem.2c01509. Epub 2023 Mar 1. PMID: 36855911.