KVN93

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130318

CAS#: N/A

Description: KVN93 is a dual-specificity tyrosine phosphorylation-regulated kinase-1A (DYRK1A) inhibitor for the treatment of Alzheimer's disease and other neurological disorders.

Chemical Structure

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KVN93
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130318
Name: KVN93
CAS#: N/A
Chemical Formula: C27H33F3N6O3
Exact Mass: 546.26
Molecular Weight: 546.600
Elemental Analysis: C, 59.33; H, 6.09; F, 10.43; N, 15.38; O, 8.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KVN93; KVN 93; KVN-93

IUPAC/Chemical Name: (4-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)(4-morpholinopiperidin-1-yl)methanone

InChi Key: FKRHOHUJMCOWDZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H33F3N6O3/c1-3-31-21-15-23(34-25-24(21)19(16-32-25)27(28,29)30)33-20-5-4-17(14-22(20)38-2)26(37)36-8-6-18(7-9-36)35-10-12-39-13-11-35/h4-5,14-16,18H,3,6-13H2,1-2H3,(H3,31,32,33,34)

SMILES Code: O=C(C1=CC=C(NC2=CC(NCC)=C3C(NC=C3C(F)(F)F)=N2)C(OC)=C1)N4CCC(N5CCOCC5)CC4

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 546.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Lee HJ, Woo H, Lee HE, Jeon H, Ryu KY, Nam JH, Jeon SG, Park H, Lee JS, Han KM, Lee SM, Kim J, Kang RJ, Lee YH, Kim JI, Hoe HS. The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation. Free Radic Biol Med. 2020 Nov 20;160:575-595. doi: 10.1016/j.freeradbiomed.2020.08.030. Epub 2020 Sep 5. PMID: 32896600.

2. Pucelik B, Barzowska A, Dąbrowski JM, Czarna A. Diabetic Kinome Inhibitors-A New Opportunity for β-Cells Restoration. Int J Mol Sci. 2021 Aug 23;22(16):9083. doi: 10.3390/ijms22169083. PMID: 34445786; PMCID: PMC8396662.