WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526828
CAS#: 1562333-92-9
Description: NVS-SM2 is a potent, orally active, small-molecule enhancer of SMN2 splicing. NVS-SM2 binds to and stabilizing the U1 snRNP:5′ss RNA complex. NVS-SM2 shows increased exon 7 inclusion and upregulated SMN protein expression in both SMA patient fibroblasts and SMNΔ7 5025-mouse myoblasts.
Hodoodo Cat#: H526828
Name: NVS-SM2
CAS#: 1562333-92-9
Chemical Formula: C23H30N6O
Exact Mass: 406.25
Molecular Weight: 406.534
Elemental Analysis: C, 67.95; H, 7.44; N, 20.67; O, 3.94
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Synonym: NVS-SM2; NVS SM2; NVSSM2 ;
IUPAC/Chemical Name: 2-(6-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)phenol
InChi Key: XSBJQWNBBMWICJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H30N6O/c1-22(2)11-17(12-23(3,4)28-22)29(5)21-9-8-19(26-27-21)18-7-6-15(10-20(18)30)16-13-24-25-14-16/h6-10,13-14,17,28,30H,11-12H2,1-5H3,(H,24,25)
SMILES Code: OC1=CC(C2=CNN=C2)=CC=C1C3=NN=C(N(C)C4CC(C)(C)NC(C)(C)C4)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 406.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Calder AN, Androphy EJ, Hodgetts KJ. Small Molecules in Development for the
Treatment of Spinal Muscular Atrophy. J Med Chem. 2016 Aug 16. [Epub ahead of
print] PubMed PMID: 27490705.