IPG7236

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130441

CAS#: N/A

Description: IPG7236 is a CCR8 antagonist that through the modulation of regulatory T-cells and cytotoxic T (CD8+ T) cells, displays anticancer effects. IPG7236 is currently undergoing Phase 1 clinical trials in the treatment of advanced solid tumors.

Chemical Structure

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IPG7236
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130441
Name: IPG7236
CAS#: N/A
Chemical Formula: C23H31N3O3S
Exact Mass: 429.21
Molecular Weight: 429.580
Elemental Analysis: C, 64.31; H, 7.27; N, 9.78; O, 11.17; S, 7.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: IPG7236; IPG 7236; IPG-7236

IUPAC/Chemical Name: (R)-2-methyl-N-(2-methyl-4-(N-(1-(1-methylpiperidin-4-yl)ethyl)sulfamoyl)phenyl)benzamide

InChi Key: PDAOEKSLYKFTKF-GOSISDBHSA-N

InChi Code: InChI=1S/C23H31N3O3S/c1-16-7-5-6-8-21(16)23(27)24-22-10-9-20(15-17(22)2)30(28,29)25-18(3)19-11-13-26(4)14-12-19/h5-10,15,18-19,25H,11-14H2,1-4H3,(H,24,27)/t18-/m1/s1

SMILES Code: O=C(NC1=CC=C(S(=O)(N[C@@H](C2CCN(C)CC2)C)=O)C=C1C)C3=CC=CC=C3C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Wu Y, Xi J, Li Y, Li Z, Zhang Y, Wang J, Fan GH. Discovery of a Potent and Selective CCR8 Small Molecular Antagonist IPG7236 for the Treatment of Cancer. J Med Chem. 2023 Apr 13;66(7):4548-4564. doi: 10.1021/acs.jmedchem.3c00030. Epub 2023 Mar 29. PMID: 36988587.

2. https://clinicaltrials.gov/ct2/show/NCT05142592