WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525583
CAS#: 394735-81-0
Description: LY-393675 is a metabotropic glutamate receptor (mGluR) antagonist. LY-393675 plays a dynamic role in signaling both on and off the plasma membrane.
Hodoodo Cat#: H525583
Name: LY-393675
CAS#: 394735-81-0
Chemical Formula: C21H21NO4S
Exact Mass: 383.12
Molecular Weight: 383.460
Elemental Analysis: C, 65.78; H, 5.52; N, 3.65; O, 16.69; S, 8.36
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Synonym: LY-393675; LY 393675; LY393675.
IUPAC/Chemical Name: 9H-Thioxanthene-9-propanoic acid, alpha-amino-alpha-(cis-3-carboxycyclobutyl)-, (alphaS)-
InChi Key: KXEPELZEWQYLKO-QRQYBIJMSA-N
InChi Code: InChI=1S/C21H21NO4S/c22-21(20(25)26,13-9-12(10-13)19(23)24)11-16-14-5-1-3-7-17(14)27-18-8-4-2-6-15(16)18/h1-8,12-13,16H,9-11,22H2,(H,23,24)(H,25,26)/t12-,13+,21-/m0/s1
SMILES Code: O=C(O)[C@]([C@H]1C[C@@H](C(O)=O)C1)(N)CC2C3=C(SC4=C2C=CC=C4)C=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 383.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Jong YJ, Kumar V, Kingston AE, Romano C, O'Malley KL. Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand. J Biol Chem. 2005 Aug 26;280(34):30469-80. Epub 2005 Jun 15. PubMed PMID: 15958386.
2: Kingston AE, Griffey K, Johnson MP, Chamberlain MJ, Kelly G, Tomlinson R, Wright RA, Johnson BG, Schoepp DD, Harris JR, Clark BP, Baker RS, Tizzano JT. Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists. Neurosci Lett. 2002 Sep 20;330(2):127-30. PubMed PMID: 12231428.
3: Zhang L, Lu Y, Chen Y, Westlund KN. Group I metabotropic glutamate receptor antagonists block secondary thermal hyperalgesia in rats with knee joint inflammation. J Pharmacol Exp Ther. 2002 Jan;300(1):149-56. PubMed PMID: 11752110.
4: Johnson MP, Kelly G, Chamberlain M. Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists. J Neuroendocrinol. 2001 Aug;13(8):670-7. PubMed PMID: 11489083.
5: Zhang LP, Chen Y, Clark BP, Sher E, Westlund KN. The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat. J Pain. 2000 Summer;1(2):151-161. PubMed PMID: 20882110; PubMed Central PMCID: PMC2946106.
6: Chen Y, Bacon G, Sher E, Clark BP, Kallman MJ, Wright RA, Johnson BG, Schoepp DD, Kingston AE. Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (+/-)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model. Neuroscience. 2000;95(3):787-93. PubMed PMID: 10670446.
7: Fitzjohn SM, Kingston AE, Lodge D, Collingridge GL. DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists. Neuropharmacology. 1999 Oct;38(10):1577-83. PubMed PMID: 10530819.
8: Salt TE, Turner JP, Kingston AE. Evaluation of agonists and antagonists acting at Group I metabotropic glutamate receptors in the thalamus in vivo. Neuropharmacology. 1999 Oct;38(10):1505-10. PubMed PMID: 10530812.