WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525909
CAS#: 444725-49-9
Description: PD-89211 is a selective dopamine D4 receptor antagonist. PD 89211 exhibits high selectivity for the DA D4.2 receptor (> 800-fold) as compared to other hDA receptor subtypes, rat brain serotonin, and adrenergic receptors. In vitro, PD 89211 had D4 receptor antagonist activity reversing quinpirole-induced [3H]thymidine uptake in CHOpro5 cells (IC50 = 2.1 nM).
Hodoodo Cat#: H525909
Name: PD-89211
CAS#: 444725-49-9
Chemical Formula: C19H21ClN4O
Exact Mass: 356.14
Molecular Weight: 356.850
Elemental Analysis: C, 63.95; H, 5.93; Cl, 9.93; N, 15.70; O, 4.48
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Synonym: PD-89211; PD 89211; PD89211.
IUPAC/Chemical Name: Benzenemethanol, 4-(4-(1H-benzimidazol-2-ylmethyl)-1-piperazinyl)-2-chloro-
InChi Key: HGMLOQOHAYKVJN-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H21ClN4O/c20-16-11-15(6-5-14(16)13-25)24-9-7-23(8-10-24)12-19-21-17-3-1-2-4-18(17)22-19/h1-6,11,25H,7-10,12-13H2,(H,21,22)
SMILES Code: c1ccc2c(c1)[nH]c(n2)CN3CCN(CC3)c4ccc(c(c4)Cl)CO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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In vitro activity: | |
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The following data is based on the product molecular weight 356.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Pugsley TA, Shih YH, Whetzel SZ, Zoski K, Van Leeuwen D, Akunne H, Mackenzie R, Heffner TG, Wustrow D, Wise LD. The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):219-26. PubMed PMID: 11817497.