VX-150
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Hodoodo CAT#: H556330

CAS#: 1793080-72-4

Description: VX-150, also known as EOS-62073, is a pro-drug of a highly selective NaV1.8 inhibitor. VX-150 is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold).

Chemical Structure

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VX-150
CAS# 1793080-72-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H556330
Name: VX-150
CAS#: 1793080-72-4
Chemical Formula: C21H17F4N2O7P
Exact Mass: 516.07
Molecular Weight: 516.341
Elemental Analysis: C, 48.85; H, 3.32; F, 14.72; N, 5.43; O, 21.69; P, 6.00

Price and Availability

Size Price Availability Quantity
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2250 2 Weeks
1g USD 3650 2 Weeks
2g USD 5650 2 Weeks
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Synonym: VX-150; VX 150; VX150; EOS-62073; EOS 62073; EOS62073;

IUPAC/Chemical Name: N-[1,2-Dihydro-2-oxo-1-[(phosphonooxy)methyl]-4-pyridinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamide

InChi Key: SQDQNNKQTHOQHO-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H17F4N2O7P/c1-12-8-14(22)3-5-17(12)34-18-9-13(21(23,24)25)2-4-16(18)20(29)26-15-6-7-27(19(28)10-15)11-33-35(30,31)32/h2-10H,11H2,1H3,(H,26,29)(H2,30,31,32)

SMILES Code: O=C(NC(C=CN1COP(O)(O)=O)=CC1=O)C2=CC=C(C(F)(F)F)C=C2OC3=CC=C(F)C=C3C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 516.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Hijma HJ, Siebenga PS, de Kam ML, Groeneveld GJ. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826. doi: 10.1093/pm/pnab032. PMID: 33543763; PMCID: PMC8346919.

2. Alles SRA, Smith PA. Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets. Front Pain Res (Lausanne). 2021 Dec 13;2:750583. doi: 10.3389/fpain.2021.750583. PMID: 35295464; PMCID: PMC8915663.