UBE-1099

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Hodoodo CAT#: H124280

CAS#: N/A

Description: UBE-1099 is a Keap1−Nrf2 inhibitor with IC50 = 47.4 nM.

Chemical Structure

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UBE-1099
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H124280
Name: UBE-1099
CAS#: N/A
Chemical Formula: C33H37F3N4O3
Exact Mass: 594.28
Molecular Weight: 594.680
Elemental Analysis: C, 66.65; H, 6.27; F, 9.58; N, 9.42; O, 8.07

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UBE-1099; UBE 1099; UBE1099

IUPAC/Chemical Name: 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-7-(trifluoromethyl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid

InChi Key: MUGQGPVBPDRCSM-MIJJZIGMSA-N

InChi Code: InChI=1S/C33H37F3N4O3/c1-7-25-18-40(17-23-15-24(33(34,35)36)10-13-28(23)43-25)16-22-14-21(9-8-19(22)2)29(32(4,5)31(41)42)26-11-12-27-30(20(26)3)37-38-39(27)6/h8-15,25,29H,7,16-18H2,1-6H3,(H,41,42)/t25-,29?/m1/s1

SMILES Code: CN1C2=CC=C(C(C3=CC=C(C)C(CN4C[C@@H](CC)OC(C=CC(C(F)(F)F)=C5)=C5C4)=C3)C(C)(C)C(O)=O)C(C)=C2N=N1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 594.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Kaseda S, Sannomiya Y, Horizono J, Kuwazuru J, Suico MA, Ogi S, Sasaki R, Sunamoto H, Fukiya H, Nishiyama H, Kamura M, Niinou S, Koyama Y, Nara F, Shuto T, Onuma K, Kai H. Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model. Kidney360. 2021 Dec 1;3(4):687-699. doi: 10.34067/KID.0004572021. PMID: 35721612; PMCID: PMC9136903.