Alectinib free base

  • CAT# 205799
  • CAS# 1256580-46-7
  • Purity

Price and availability

Structure

Structure of Alectinib free base

CAS# 1256580-46-7

Size Price Availability Quantity
1 g$ 950

2 weeks

$950.00Add to cart

5 g$ 2950

2 weeks

$2,950.00Add to cart

10 g$ 3650

2 weeks

$3,650.00Add to cart

20 g$ 5650

2 weeks

$5,650.00Add to cart

Pricing updated 2019-06-05 . Prices are subject to change without notice
Description:

Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth. Alectinib was approved in Dec. 2015.

Technical data

IUPAC/Chemnical Name9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
Synonym nameAF 802; AF-802; AF802; CH5424802; CH5424802; CH 5424802; RO5424802; RO 5424802; RO5424802, Alectinib; brand name: Alecensa
CAS#1256580-46-7
Related CAS#1256580-46-7 (free base) 1256589-74-8 (HCl)
MFCDMFCD19440988
PubChem#49806720
Molecule FormlaC30H34N4O2
Molecule Weight482.6280
AppearanceWhite to off-white solid powder
Purity98%
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage ConditionDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Stability>2 years if stored properly
Harmonized System (HS) Code 2916.39.79.00
SMILES code N#CC1=CC2=C(C=C1)C3=C(C(C)(C)C4=CC(N5CCC(N6CCOCC6)CC5)=C(CC)C=C4C3=O)N2
InChi codeInChi Code: InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
InChi keyKDGFLJKFZUIJMX-UHFFFAOYSA-N