PARPI F-18

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124820

CAS#: 1883580-48-0

Description: PARPI F-18 is a bimodal fluorescent/positron emission tomography (PET) agent.

Chemical Structure

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PARPI F-18
CAS# 1883580-48-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H124820
Name: PARPI F-18
CAS#: 1883580-48-0
Chemical Formula: C27H22F2N4O3
Exact Mass: 488.17
Molecular Weight: 488.490
Elemental Analysis: C, 66.39; H, 4.54; F, 7.78; N, 11.47; O, 9.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: (18F)Parpi; Parpi F-18; FT8GT4M7UG; UNII-FT8GT4M7UG

IUPAC/Chemical Name: 4-(4-fluoro-3-(4-(4-fluorobenzoyl)piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one

InChi Key: LTZZZXXIKHHTMO-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H22F2N4O3/c28-19-8-6-18(7-9-19)26(35)32-11-13-33(14-12-32)27(36)22-15-17(5-10-23(22)29)16-24-20-3-1-2-4-21(20)25(34)31-30-24/h1-10,15H,11-14,16H2,(H,31,34)

SMILES Code: C1CN(CCN1C(=O)C2=CC=C(C=C2)F)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 488.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Carlucci G, Carney B, Brand C, Kossatz S, Irwin CP, Carlin SD, Keliher EJ,
Weber W, Reiner T. Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma.
Mol Imaging Biol. 2015 Dec;17(6):848-55. doi: 10.1007/s11307-015-0858-0. PMID:
25895168; PMCID: PMC4609241.

2: Huang T, Hu P, Banizs AB, He J. Initial evaluation of Cu-64 labeled PARPi-
DOTA PET imaging in mice with mesothelioma. Bioorg Med Chem Lett. 2017 Aug
1;27(15):3472-3476. doi: 10.1016/j.bmcl.2017.05.077. Epub 2017 May 26. PMID:
28587822; PMCID: PMC5724367.