WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124907
CAS#: 1639419-51-4 (sulfate)
Description: Ivarmacitinib, also known as SHR0302, is a novel potent JAK inhibitor which blocks JAK/STAT3 signaling, suppresses proliferation, migration and collagen production, and induces the apoptosis of hepatic stellate cells. SHR0302 may attenuate the severity of AA rats, partially through reducing Th17 function and total B cell proportion by inhibiting JAK1-STAT3 phosphorylation.
Hodoodo Cat#: H124907
Name: Ivarmacitinib sulfate
CAS#: 1639419-51-4 (sulfate)
Chemical Formula: C18H24N8O6S2
Exact Mass: 512.13
Molecular Weight: 512.560
Elemental Analysis: C, 42.18; H, 4.72; N, 21.86; O, 18.73; S, 12.51
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Related CAS #: 1445987-21-2 (free base) 1639419-51-4 (sulfate) 1639419-53-6 (HCl),
Synonym: Ivarmacitinib sulfate; Ivarmacitinib sulfate [USAN]; CN7B3Z5G04; SHR0302 SULFATE
IUPAC/Chemical Name: (3aR,6aS)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxamide;sulfuric acid
InChi Key: XVVWQCLRGHYWPI-ZLURZNERSA-N
InChi Code: InChI=1S/C18H22N8O2S.H2O4S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17;1-5(2,3)4/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27);(H2,1,2,3,4)/t10-,11+,12?;
SMILES Code: O=S(O)(O)=O.O=C(N1C[C@]2([H])[C@](CC(N(C)C3=C4C(NC=C4)=NC=N3)C2)([H])C1)NC5=NC(OC)=NS5
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 512.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
