WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H326903
CAS#: 124012-42-6
Description: Galocitabine, also known as Neofrutulon; RO-091390; RO-09-1390, is a thymidylate synthase inhibitor potentially for the treatment of cancer.
Hodoodo Cat#: H326903
Name: Galocitabine
CAS#: 124012-42-6
Chemical Formula: C19H22FN3O8
Exact Mass: 439.14
Molecular Weight: 439.396
Elemental Analysis: C, 51.94; H, 5.05; F, 4.32; N, 9.56; O, 29.13
This product is not in stock, which may be available by custom synthesis.
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Synonym: Neofrutulon; RO-091390; RO 091390; RO091390; RO-09-1390; Galocitabine
IUPAC/Chemical Name: N-(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-3,4,5-trimethoxybenzamide
InChi Key: TVYPSLDUBVTDIS-FUOMVGGVSA-N
InChi Code: InChI=1S/C19H22FN3O8/c1-8-13(24)14(25)18(31-8)23-7-10(20)16(22-19(23)27)21-17(26)9-5-11(28-2)15(30-4)12(6-9)29-3/h5-8,13-14,18,24-25H,1-4H3,(H,21,22,26,27)/t8-,13-,14-,18-/m1/s1
SMILES Code: O=C(NC(C(F)=CN1[C@H]2[C@@H]([C@@H]([C@@H](C)O2)O)O)=NC1=O)C3=CC(OC)=C(OC)C(OC)=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 439.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Shindoh H, Kawashima A, Shishido N, Nakano K, Kobayashi K, Horii I.
Relationship between AUC of 5'-DFUR and toxicity of capecitabine,
fluoropyrimidine carbamate analogs, and 5'-DFUR in monkeys, mice, and rats. J
Toxicol Sci. 2006 Aug;31(3):265-85. PubMed PMID: 16960436.
2: Funaki T, Onodera H, Ogawa K, Ichihara S, Fukazawa H, Kuruma I. Simultaneous
determination of a new anticancer drug galocitabine and its metabolites in blood
by high-performance liquid chromatography. J Pharm Biomed Anal. 1993
Apr-May;11(4-5):379-84. PubMed PMID: 8357875.