WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H328208
CAS#: 7246-20-0 (sodium)
Description: Triclofos Sodium, also known as Triclofos and SCH-10159, is a drug used to treat insomnia and used for sedation.
Hodoodo Cat#: H328208
Name: Triclofos Sodium
CAS#: 7246-20-0 (sodium)
Chemical Formula: C2H3Cl3NaO4P
Exact Mass: 0.00
Molecular Weight: 251.356
Elemental Analysis: C, 9.56; H, 1.20; Cl, 42.31; Na, 9.15; O, 25.46; P, 12.32
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Related CAS #: 7246-20-0 (sodium) 306-52-5 (free acid)
Synonym: Triclofos Sodium; SCH-10159; SCH 10159; SCH10159
IUPAC/Chemical Name: sodium 2,2,2-trichloroethyl hydrogen phosphate
InChi Key: WFKJEZKHPGDCRK-UHFFFAOYSA-M
InChi Code: InChI=1S/C2H4Cl3O4P.Na/c3-2(4,5)1-9-10(6,7)8;/h1H2,(H2,6,7,8);/q;+1/p-1
SMILES Code: ClC(Cl)(Cl)COP(O)([O-])=O.[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# 7246-20-0(Triclofos Sodium) 306-52-5 (Triclofos)
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The following data is based on the product molecular weight 251.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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| In vivo protocol: |
1: Radhika KP, Sreejit MS, Ramadas KT. Efficacy of midazolam as oral premedication in children in comparison to triclofos sodium. Indian J Anaesth. 2016 Jun;60(6):415-9. doi: 10.4103/0019-5049.183389. PubMed PMID: 27330204; PubMed Central PMCID: PMC4910482.
2: Fujimoto W, Matsuo-Kanda A. Multilocalized non-pigmenting fixed drug eruption caused by triclofos sodium. Eur J Dermatol. 2014 May-Jun;24(3):380-1. doi: 10.1684/ejd.2014.2314. PubMed PMID: 24721678.
3: Akaike H, Kondo E, Kono M, Kato A. [Hypnotic effects of ramelteon during electroencephalography]. No To Hattatsu. 2016 Jan;48(1):10-3. Japanese. PubMed PMID: 27012103.
4: Jackson EA, Rabbette PS, Dezateux C, Hatch DJ, Stocks J. The effect of triclofos sodium sedation on respiratory rate, oxygen saturation, and heart rate in infants and young children. Pediatr Pulmonol. 1991;10(1):40-5. PubMed PMID: 2003045.
5: Baiotti G. Comparative trial of a new hypnotic (Finorgal) with nitrazepam and triclofos sodium. J Int Med Res. 1979;7(5):383-6. PubMed PMID: 387491.
6: McRae JD, Tadros LM. Hydrolysis kinetics of the monophosphate ester triclofos sodium. J Pharm Sci. 1978 May;67(5):631-5. PubMed PMID: 25331.
7: Triclofos sodium (Triclos) for insomnia. Med Lett Drugs Ther. 1972 Oct 13;14(21):78-80. PubMed PMID: 4567567.
8: Sakai H, Kirino E, Inoue R, Arai H. Transient administration of triclofos sodium is helpful in minimizing anticonvulsants under polypharmacy. Psychiatry Clin Neurosci. 2006 Dec;60(6):776-7. PubMed PMID: 17109718.
9: Millichap JG. Electroencephalographic evaluation of triclofos sodium sedation in children. Am J Dis Child. 1972 Oct;124(4):526-7. PubMed PMID: 4638712.
10: Shahar E, Shnaps Y, Frand M. Acute triclofos poisoning in a preterm infant. Clin Pediatr (Phila). 1979 Nov;18(11):706-7. PubMed PMID: 574069.
11: Rabbette PS, Dezateux CA, Fletcher ME, Costeloe KL, Stocks J. Influence of sedation on the Hering-Breuer inflation reflex in healthy infants. Pediatr Pulmonol. 1991;11(3):217-22. PubMed PMID: 1758743.
12: Gozal D, Drenger B, Levin PD, Kadari A, Gozal Y. A pediatric sedation/anesthesia program with dedicated care by anesthesiologists and nurses for procedures outside the operating room. J Pediatr. 2004 Jul;145(1):47-52. PubMed PMID: 15238906.
13: Asami T, Suzuki H, Yazaki S, Sato S, Uchiyama M. Effects of thyroid hormone deficiency on electrocardiogram findings of congenitally hypothyroid neonates. Thyroid. 2001 Aug;11(8):765-8. PubMed PMID: 11525269.
14: Stocks J, Dezateux CA, Jackson EA, Hoo AF, Costeloe KL, Wade AM. Analysis of tidal breathing parameters in infancy: how variable is TPTEF:TE? Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1347-54. PubMed PMID: 7952563.
