WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H326970
CAS#: 1266548-75-7
Description: Hyzetimibe, also known as HS-25, is a cholesterol absorption blocker potentially for the treatment of hypercholesterolemia.
Hodoodo Cat#: H326970
Name: Hyzetimibe
CAS#: 1266548-75-7
Chemical Formula: C25H21F2NO3
Exact Mass: 421.15
Molecular Weight: 421.444
Elemental Analysis: C, 71.25; H, 5.02; F, 9.02; N, 3.32; O, 11.39
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Synonym: Hyzetimibe; HS 25; HS-25; HS25.
IUPAC/Chemical Name: (3R,4S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-4-hydroxybut-2-enyl)-4-(4-hydroxyphenyl)-2-azetidinone
InChi Key: HEHHPZYUXSFAPV-GLGQCLCGSA-N
InChi Code: InChI=1S/C25H21F2NO3/c26-19-6-1-16(2-7-19)18(15-29)5-14-23-24(17-3-12-22(30)13-4-17)28(25(23)31)21-10-8-20(27)9-11-21/h1-13,23-24,29-30H,14-15H2/b18-5-/t23-,24-/m1/s1
SMILES Code: O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1C/C=C(C4=CC=C(F)C=C4)/CO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 421.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Chen J, Lou H, Jiang B, Shao R, Ruan Z, Wang J. Simultaneous determination of
hyzetimibe and its main active metabolite in plasma by LC-MS/MS and its
application in PK study. Bioanalysis. 2015;7(15):1857-67. doi:
10.4155/bio.15.114. PubMed PMID: 26295987.
2: Ruan Z, Jiang B, Chen J, Zhang X, Lou H, Xiang M, Shao Q, Wang J.
Pharmacokinetics, pharmacodynamics, safety, and tolerability of hyzetimibe
(HS-25) in healthy Chinese subjects. J Clin Pharmacol. 2014 Oct;54(10):1144-52.
doi: 10.1002/jcph.310. Epub 2014 Apr 21. PubMed PMID: 24752831.