Pimavanserin tartrate
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Hodoodo CAT#: H326973

CAS#: 706782-28-7 (tartrate)

Description: Pimavanserin, also known as ACP-103, is a non-dopaminergic atypical antipsychotic for the treatment of Parkinson's disease psychosis and schizophrenia. Pimavanserin has a unique mechanism of action relative to other antipsychotics, behaving as a selective inverse agonist of the serotonin 5-HT2A receptor, with 40-fold selectivity for this site over the 5-HT2C receptor and no significant affinity or activity at the 5-HT2B receptor or dopamine receptors. It was approved by the FDA to treat hallucinations and delusions associated with psychosis experienced by some people with Parkinson's disease on April 29, 2016.

Chemical Structure

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Pimavanserin tartrate
CAS# 706782-28-7 (tartrate)
Instruction

Theoretical Analysis

Hodoodo Cat#: H326973
Name: Pimavanserin tartrate
CAS#: 706782-28-7 (tartrate)
Chemical Formula: C54H74F2N6O10
Exact Mass: 0.00
Molecular Weight: 1,005.210
Elemental Analysis: C, 64.52; H, 7.42; F, 3.78; N, 8.36; O, 15.92

Price and Availability

Size Price Availability Quantity
100mg USD 150 Ready to ship
200mg USD 250 Ready to ship
500mg USD 450 Ready to ship
1g USD 800 Ready to ship
2g USD 1350 Ready to ship
5g USD 2250 2 Weeks
10g USD 3650 2 Weeks
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Related CAS #: 706779-91-1 (free base)   706782-28-7 (tartrate)  

Synonym: Pimavanserin tartrate; ACP-103; ACP 103; ACP103; Pimavanserin; trade name: Nuplazid.

IUPAC/Chemical Name: 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea, ((2R,3R)-2,3-dihydroxysuccinate) (2:1)

InChi Key: RGSULKHNAKTFIZ-CEAXSRTFSA-N

InChi Code: InChI=1S/2C25H34FN3O2.C4H6O6/c2*1-19(2)18-31-24-10-6-20(7-11-24)16-27-25(30)29(23-12-14-28(3)15-13-23)17-21-4-8-22(26)9-5-21;5-1(3(7)8)2(6)4(9)10/h2*4-11,19,23H,12-18H2,1-3H3,(H,27,30);1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

SMILES Code: O=C(NCC1=CC=C(OCC(C)C)C=C1)N(CC2=CC=C(F)C=C2)C3CCN(C)CC3.O=C(NCC4=CC=C(OCC(C)C)C=C4)N(CC5=CC=C(F)C=C5)C6CCN(C)CC6.O=C(O)[C@H](O)[C@@H](O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 706779-91-1 ( Pimavanserin ) 706782-28-7 (Pimavanserin tartrate)

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 70.0 69.60

Preparing Stock Solutions

The following data is based on the product molecular weight 1,005.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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