WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H328909
CAS#: 73-09-6 (free base)
Description: Etozolin, also known as Diulozin and W-2900A, is a diuretic agent that is used to treat oedema and hypertension.
Hodoodo Cat#: H328909
Name: Etozolin
CAS#: 73-09-6 (free base)
Chemical Formula: C13H20N2O3S
Exact Mass: 284.12
Molecular Weight: 284.374
Elemental Analysis: C, 54.91; H, 7.09; N, 9.85; O, 16.88; S, 11.27
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 53-90-7 (HCl) 73-09-6 (free base)
Synonym: Etozolin; W-2900A; W 2900A; W2900A; GO 687; GO-687; GO687; Diulozin; Elkapin
IUPAC/Chemical Name: ethyl (E)-2-(3-methyl-4-oxo-5-(piperidin-1-yl)thiazolidin-2-ylidene)acetate
InChi Key: ZCKKHYXUQFTBIK-MDZDMXLPSA-N
InChi Code: InChI=1S/C13H20N2O3S/c1-3-18-11(16)9-10-14(2)12(17)13(19-10)15-7-5-4-6-8-15/h9,13H,3-8H2,1-2H3/b10-9+
SMILES Code: O=C(OCC)/C=C(N1C)/SC(N2CCCCC2)C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 284.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Nami R, Lucani B, Pavese G, Panza F, Moscato D, Martinelli M, Gennari C. Acute antihypertensive, diuretic and metabolic effects of etozolin and chlorthalidone. Panminerva Med. 1991 Jul-Sep;33(3):157-63. PubMed PMID: 1771100.
2: Knauf H, Missmahl M, Schölmerich J, Gerok W, Mutschler E. Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites. Arzneimittelforschung. 1987 Dec;37(12):1385-8. PubMed PMID: 3449068.
3: Nau H, Steldinger R, Ivan E. Placental transfer of etozolin and ozolinone during the first half of gestation in man. Eur J Clin Pharmacol. 1982;23(3):253-60. PubMed PMID: 7173295.
4: Battaglia A, Adamo M, Di Stefano G, Gargano F. [Etozolin and captopril in the treatment of arterial hypertension]. Clin Ter. 1990 Feb 15;132(3):173-9. Italian. PubMed PMID: 2139827.
5: Muiesan G, Agabiti-Rosei E. Etozolin monotherapy and combination with verapamil in essential hypertension. J Hypertens Suppl. 1989 Dec;7(6):S278-9. PubMed PMID: 2698939.
6: Knauf H, Hasenfuss G, Wais U, Schollmeyer P, Mutschler E. Independent of etozolin elimination of kidney function. Single dose experiments in patients with renal insufficiency. Arzneimittelforschung. 1980;30(10):1791-3. PubMed PMID: 7192116.
7: Haslbeck M, Renner R, Kemmler W, Schneider B, Mehnert H. [Effect on carbohydrate metabolism of a new saluretic, etozolin]. Fortschr Med. 1979 Oct 25;97(40):1825-30. German. PubMed PMID: 396216.
8: Biamino G. [Comparative studies on the diuretic activities of Etozolin and a reference compound in normal volunteers (author's transl)]. Arzneimittelforschung. 1977;27(9a):1814-7. German. PubMed PMID: 578772.
9: Hengy H, Vollmer KO, Gladigau V, Kölle EU. Assay of etozolin and its main metabolite, ozolinone, in plasma by high performance liquid chromatography. Arzneimittelforschung. 1980;30(10):1788-90. PubMed PMID: 7192115.
10: Biamino G, Kopp H, Rudroff W, Schneider B. [Studies on the diuretic effects of etozolin (Elkapin) in heart failure - a comparison with the loop diuretic agent furosemide (author's transl)]. Med Klin. 1979 Apr 20;74(16):624-30. German. PubMed PMID: 460026.
11: Cellina G, Binaghi P, De Carolis ME, Limonta A, Lo Cicero G, Di Michele R. [Arterial hypertension in perimenopausal women; tolerability of etozolin]. Minerva Cardioangiol. 1990 Jul-Aug;38(7-8):341-4. Italian. PubMed PMID: 2080024.
12: Greven J, Heidenreich O. Effect of Etozolin on whole kidney function and fluid and electrolyte reabsorption in rat proximal convoluted tubules and loops of Henle. Arzneimittelforschung. 1977;27(9a):1755-7. PubMed PMID: 578764.
13: Herrmann M, Bahrmann H, Birkenmayer E, Ganser V, Heldt W, Steinbrecher W. [On the pharmacology of Etozolin (author's transl)]. Arzneimittelforschung. 1977;27(9a):1745-54. German. PubMed PMID: 578763.
14: Musini VM, Rezapour P, Wright JM, Bassett K, Jauca CD. Blood pressure-lowering efficacy of loop diuretics for primary hypertension. Cochrane Database Syst Rev. 2015 May 22;(5):CD003825. doi: 10.1002/14651858.CD003825.pub4. Review. PubMed PMID: 26000442.
15: Knauf H, Liebig R, Schollmeyer P, Rosenthal J, Kölle EU, Mutschler E. Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function. Eur J Clin Pharmacol. 1984;26(6):687-93. PubMed PMID: 6386484.
