WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H328920
CAS#: 18694-40-1
Description: Epirizole, also known as DA-398, is a pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.
Hodoodo Cat#: H328920
Name: Epirizole
CAS#: 18694-40-1
Chemical Formula: C11H14N4O2
Exact Mass: 234.11
Molecular Weight: 234.259
Elemental Analysis: C, 56.40; H, 6.02; N, 23.92; O, 13.66
This product is not in stock, which may be available by custom synthesis.
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Synonym: Epirizole; DA-398; DA398; DA 398; Methopyrimazole; Dalex; Mebron;
IUPAC/Chemical Name: 4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine
InChi Key: RHAXSHUQNIEUEY-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3
SMILES Code: CC1=CC(OC)=NC(N2N=C(C)C=C2OC)=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 234.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Kawashima Y, Lin SY, Ogawa M, Handa T, Takenaka H. Preparations of agglomerated crystals of polymorphic mixtures and a new complex of indomethacin-epirizole by the spherical crystallization technique. J Pharm Sci. 1985 Nov;74(11):1152-6. PubMed PMID: 4087173.
2: Khomenko T, Deng X, Ahluwalia A, Tarnawski A, Patel KN, Sandor Z, Szabo S. STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration. Dig Dis Sci. 2014 Feb;59(2):297-306. doi: 10.1007/s10620-013-2807-6. Epub 2014 Jan 3. PubMed PMID: 24385009.
3: Gallo M, La Montagna G. [Controlled research on the use of epirizole in the therapy of rheumatoid arthritis]. Clin Ter. 1983 Sep 30;106(6):429-33. Italian. PubMed PMID: 6357595.
4: Rovira M, Huang W, Yusuff S, Shim JS, Ferrante AA, Liu JO, Parsons MJ. Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19264-9. doi: 10.1073/pnas.1113081108. Epub 2011 Nov 14. PubMed PMID: 22084084; PubMed Central PMCID: PMC3228434.
5: Ueshima K, Takeuchi K, Ohuchi T, Okabe S. Acid secretory and duodenal ulcerogenic responses induced by mepirizole in anesthetized rats. Relation to body temperature. Dig Dis Sci. 1994 Aug;39(8):1625-32. PubMed PMID: 7914158.
6: Okabe S, Ishihara Y, Inoo H, Tanaka H. Mepirizole-induced duodenal ulcers in rats and their pathogenesis. Dig Dis Sci. 1982 Mar;27(3):242-9. PubMed PMID: 6122549.
7: Tabata K, Jacobson ED, Chen MH, Murphy RF, Joffe SN. Decrease in alkaline secretion during duodenal ulceration induced by mepirizole in rats. Gastroenterology. 1984 Aug;87(2):396-401. PubMed PMID: 6735082.
8: Tanaka Y, Sano M. Analytical studies on mepirizole and its metabolites. II. Identification of the human urinary metabolites of mepirizole with stable isotope labeling. Chem Pharm Bull (Tokyo). 1976 Apr;24(4):804-7. PubMed PMID: 949819.
9: Sano M, Tanaka Y. Analytical studies on mepirizole and its metabolites. I. Mass spectra of mepirizole and its some metabolites. Chem Pharm Bull (Tokyo). 1975 Jan;23(1):209-16. PubMed PMID: 1164778.
10: Onoa GB, Moreno V. Study of the modifications caused by cisplatin, transplatin, and Pd(II) and Pt(II) mepirizole derivatives on pBR322 DNA by atomic force microscopy. Int J Pharm. 2002 Oct 1;245(1-2):55-65. PubMed PMID: 12270242.
11: Onoa GB, Moreno V, Font-Bardia M, Solans X, Pérez JM, Alonso C. Structural and cytotoxic study of new Pt(II) and Pd(II) complexes with the bi-heterocyclic ligand mepirizole. J Inorg Biochem. 1999 Jun 30;75(3):205-12. PubMed PMID: 10474205.
12: Ikeda M, Maruyama K, Nobuhara Y, Yamada T, Okabe S. Synthesis and cytoprotective antiulcer activity of 2- or 4-(1H-pyrazol-1-yl)pyrimidine derivatives related to mepirizole and dulcerozine. Chem Pharm Bull (Tokyo). 1996 Sep;44(9):1700-6. PubMed PMID: 8855364.
13: Kline TJ, Pihan G, Szabo S. Biphasic effect of duodenal ulcerogens on gastric emptying in the rat. Dig Dis Sci. 1988 Aug;33(8):926-30. PubMed PMID: 3260551.
14: Boonyaratavej N. Clinical evaluation of mepirizole. J Med Assoc Thai. 1979 Dec;62(12):682-5. PubMed PMID: 536659.
15: Albet C, Beneyto JE, Colomé J. [Spectrophotodensitometric determination of mepirizole and its N-methylated isomer]. Boll Chim Farm. 1975 Oct;114(10):569-76. Spanish. PubMed PMID: 1220714.
