WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526888
CAS#: 169815-40-1 (HCl)
Description: AQ-13 is an aminoquinoline agent potentially for treatment of malaria. AQ-13 is effective against chloroquine-resistant strains of Plasmodium falciparum. It is structurally similar to the widely used chloroquine diphosphate (CQ). Malaria is a major health problem in endemic countries and chemotherapy remains the most important tool in combating it.
Hodoodo Cat#: H526888
Name: AQ-13 dihydrochloride
CAS#: 169815-40-1 (HCl)
Chemical Formula: C16H24Cl3N3
Exact Mass: 0.00
Molecular Weight: 364.739
Elemental Analysis: C, 52.69; H, 6.63; Cl, 29.16; N, 11.52
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Related CAS #: 169815-40-1 (HCl) 32571-49-6 (free base)
Synonym: AQ-13 dihydrochloride; AQ13; AQ 13.
IUPAC/Chemical Name: N1-(7-chloroquinolin-4-yl)-N3,N3-diethylpropane-1,3-diamine dihydrochloride
InChi Key: ZNHBPWZRWNFJPN-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H22ClN3.2ClH/c1-3-20(4-2)11-5-9-18-15-8-10-19-16-12-13(17)6-7-14(15)16;;/h6-8,10,12H,3-5,9,11H2,1-2H3,(H,18,19);2*1H
SMILES Code: CCN(CC)CCCNC1=CC=NC2=CC(Cl)=CC=C12.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# CAS#32571-49-6 (AQ-13 free base) CAS#169815-40-1 (AQ 13 dihydrochloride)
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The following data is based on the product molecular weight 364.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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| In vivo protocol: |
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5: Nishishiro M, Kurihara T, Wakabayashi H, Sakagami H. Effect of tropolone, azulene and azulenequinone derivatives on prostaglandin E2 production by activated macrophage-like cells. Anticancer Res. 2009 Jan;29(1):379-83. PubMed PMID: 19331176.
6: Owusu-Agyei S, Asante KP, Owusu R, Adjuik M, Amenga-Etego S, Dosoo DK, Gyapong J, Greenwood B, Chandramohan D. An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria. PLoS One. 2008 Jun 25;3(6):e2530. doi: 10.1371/journal.pone.0002530. PubMed PMID: 18575626; PubMed Central PMCID: PMC2430614.
7: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Dec;29(10):697-735. PubMed PMID: 18200333.
8: Mzayek F, Deng H, Mather FJ, Wasilevich EC, Liu H, Hadi CM, Chansolme DH, Murphy HA, Melek BH, Tenaglia AN, Mushatt DM, Dreisbach AW, Lertora JJ, Krogstad DJ. Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers. PLoS Clin Trials. 2007 Jan 5;2(1):e6. PubMed PMID: 17213921; PubMed Central PMCID: PMC1764434.
9: Deng H, Liu H, Krogstad FM, Krogstad DJ. Sensitive fluorescence HPLC assay for AQ-13, a candidate aminoquinoline antimalarial, that also detects chloroquine and N-dealkylated metabolites. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Apr 3;833(2):122-8. Epub 2006 Jan 18. PubMed PMID: 16520100.
10: Ramanathan-Girish S, Catz P, Creek MR, Wu B, Thomas D, Krogstad DJ, De D, Mirsalis JC, Green CE. Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques. Int J Toxicol. 2004 May-Jun;23(3):179-89. PubMed PMID: 15204721.
11: Riccio ES, Lee PS, Winegar RA, Krogstad DJ, De D, Mirsalis JC. Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environ Mol Mutagen. 2001;38(1):69-79. PubMed PMID: 11473390.
