WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526892
CAS#: 91595-86-7
Description: Pipoxazole, also known as COR-32-24 amd COR3224, is an adrenergic receptor antagonist potentially for the treatment of depression.
Hodoodo Cat#: H526892
Name: Pipoxazole
CAS#: 91595-86-7
Chemical Formula: C14H20N4O
Exact Mass: 260.16
Molecular Weight: 260.341
Elemental Analysis: C, 64.59; H, 7.74; N, 21.52; O, 6.15
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Synonym: COR-32-24; COR32-24; COR 32-24; COR-3224; COR3224; COR 3224. Pipoxazole
IUPAC/Chemical Name: 4,5-Dihydro-5-(4-phenyl-1-piperazinylmethyl)-2-oxazolamine
InChi Key: XSZLHACSCSAKOF-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H20N4O/c15-14-16-10-13(19-14)11-17-6-8-18(9-7-17)12-4-2-1-3-5-12/h1-5,13H,6-11H2,(H2,15,16)
SMILES Code: NC1=NCC(CN2CCN(C3=CC=CC=C3)CC2)O1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 260.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Damaj MI, Urien S, Trouvin JH, Chanut E, Lambrey B, Jacquot C. In vivo evidence for carrier-mediated brain uptake of a new 2-amino-2-oxazoline (COR3224) via the purine transport system in rat. Brain Res. 1991 Jul 19;554(1-2):333-5. PubMed PMID: 1933316.
2: Damaj MI, Trouvin JH, Lambrey B, Jacquot C. Determination of a new 2-amino-2-oxazoline (COR 3224) in plasma and brain tissue of the rat by high-performance liquid chromatography with electrochemical detection. J Chromatogr. 1991 Feb 15;563(2):476-9. PubMed PMID: 2056013.
3: Neau B, Damaj I, Lambrey B, Akbaraly JP, Roux J, Perrissoud D, Jacquot J. COR3224--a new antidepressant: pharmacokinetics and metabolism in rat. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:77-9. PubMed PMID: 1820940.
4: Damaj MI, Trouvin JH, Lambrey B, Jacquot C. Kinetics and brain uptake of COR3224, a new 2-amino-2-oxazoline, in rats. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:52-6. PubMed PMID: 1820934.
5: Damaj MI, Trouvin JH, Lambrey B, Jacquot C. High-performance liquid chromatography of a new 2-amino-2-oxazoline: application to pharmacokinetic studies in dogs. J Pharm Sci. 1990 Jun;79(6):516-8. PubMed PMID: 2395095.
6: Jarry C, Bosc JJ, Ouhabi J, Carpy A. 2-Aminooxazolines, I: Crystal and molecular structure of 5-(1-aryl-4-piperazino)methyl-substituted derivatives with antidepressant activity. Arch Pharm (Weinheim). 1990 Mar;323(3):157-61. PubMed PMID: 2344261.
7: Bourin M, Creuzet MH, Jarry C, Colombel MC. A 2-amino-2-oxazoline derivative as an antidepressant in mice. Arzneimittelforschung. 1988 May;38(5):666-8. PubMed PMID: 3261982.
