WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H328039
CAS#: 82101-08-4 (HCl)
Description: Flerobuterol, also known as CRL-40996, is a β adrenergic receptor agonist potentially for the treatment of major depressive disorder. Flerobuterol enhances serotonergic neurotransmission: an electrophysiological study in the rat brain. Flerobuterol, similar to other beta-adrenergic agonists, acutely increases 5-HT synthesis, in part, through an elevation of brain Trp availability.
Hodoodo Cat#: H328039
Name: Flerobuterol HCl
CAS#: 82101-08-4 (HCl)
Chemical Formula: C12H19ClFNO
Exact Mass: 247.11
Molecular Weight: 247.738
Elemental Analysis: C, 58.18; H, 7.73; Cl, 14.31; F, 7.67; N, 5.65; O, 6.46
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Synonym: Flerobuterol hydrochloride; CRL-40996; CRL 40996; CRL40996.
IUPAC/Chemical Name: alpha-(((1,1-Dimethylethyl)amino)methyl)-2-fluorobenzenemethanol hydrochloride
InChi Key: NXNFXCMJTRKWFF-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H18FNO.ClH/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13;/h4-7,11,14-15H,8H2,1-3H3;1H
SMILES Code: OC(CNC(C)(C)C)C1=CC=CC=C1F.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# 82101-08-4 (Flerobuterol hydrochloride) 82101-10-8 (Flerobuterol free base)
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The following data is based on the product molecular weight 247.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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1: Morin D, Sapena R, Tillement JP, Urien S. Evidence for different interactions between beta(1)- and beta(2)-adrenoceptor subtypes with adenylyl cyclase in the rat brain: a concentration-response study using forskolin. Pharmacol Res. 2000 Apr;41(4):435-43. PubMed PMID: 10704268.
2: Tsuiki K, Blier P, Diksic M. Effect of the beta-adrenoceptor agonist flerobuterol on serotonin synthesis in the rat brain. Biochem Pharmacol. 2000 Mar 15;59(6):673-9. PubMed PMID: 10677584.
3: Toet AE, te Biesebeek JD, Vleeming W, Wemer J, Meulenbelt J, de Wildt DJ. Reduced survival after isoprenaline/dopamine in d,l-propranolol intoxicated rats. Hum Exp Toxicol. 1996 Feb;15(2):120-8. PubMed PMID: 8645502.
4: Zini R, Morin D, Martin P, Puech AJ, Tillement JP. Interactions of flerobuterol, an antidepressant drug candidate, with beta adrenoceptors in the rat brain. J Pharmacol Exp Ther. 1991 Oct;259(1):414-22. PubMed PMID: 1681091.
5: Duteil J, Rambert FA, Pointeau AM, Mangiameli P, Assous E. Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice. Fundam Clin Pharmacol. 1991;5(8):695-708. PubMed PMID: 1686009.
6: Bouthillier A, Blier P, de Montigny C. Flerobuterol, a beta-adrenoceptor agonist, enhances serotonergic neurotransmission: an electrophysiological study in the rat brain. Psychopharmacology (Berl). 1991;103(3):357-65. PubMed PMID: 1676181.
7: Chariot J, De La Tour J, Vaille C, Rozé C. Effects of CRL 40827 and salbutamol on exocrine pancreatic secretion in rats. Eur J Pharmacol. 1988 Jan 27;146(1):17-25. PubMed PMID: 2895009.
8: Lang F, Perrier E, Pellet J. [Noradrenergic hypothesis in anorexia nervosa: prospective study using beta-stimulant therapy]. Ann Med Psychol (Paris). 1983 Sep-Oct;141(8):918-25. French. PubMed PMID: 6153059.
