WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526160
CAS#: 103295-92-7
Description: Ro 18-3981 inhibits myocardial Ca2+ channels. The KD value of Ro 18-3981 (1.0 nM) was similar to the IC50 value for blockade of ICa at a Vh of -20 mV (2.3 nM), i.e. at a level of near-maximal depolarization.
Hodoodo Cat#: H526160
Name: Ro 18-3981
CAS#: 103295-92-7
Chemical Formula: C24H33N3O8S-
Exact Mass: 523.20
Molecular Weight: 523.600
Elemental Analysis: C, 55.05; H, 6.35; N, 8.03; O, 24.44; S, 6.12
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Synonym: Ro 18-3981; Ro 183981; Ro-18-3981.
IUPAC/Chemical Name: 2-Propoxyethyl-1,4-dihydro-5-((isopropylsulfamoyl)acetyl)-2,6-dimethyl-4-(3-nitrophenyl)nicotinate
InChi Key: PFWSHFUEGUFZHV-UHFFFAOYSA-M
InChi Code: InChI=1S/C24H34N3O8S/c1-6-11-35-12-10-24(5)22(23(29)30)21(17-8-7-9-18(13-17)27(31)32)20(16(4)25-24)19(28)14-36(33,34)26-15(2)3/h7-9,13,15,21,25-26H,6,10-12,14H2,1-5H3,(H,29,30)/p-1
SMILES Code: O=C([O-])C1=C(C)(CCOCCC)NC(C)=C(C(CS(=O)(NC(C)C)=O)=O)C1C2=CC=CC([N+]([O-])=O)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 523.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Holck MI. Alpha 1-adrenoceptor reserve and effects of a Ca2+ entry blocker (Ro 18-3981) on aorta of spontaneously hypertensive rats. Eur J Pharmacol. 1988 Mar 22;148(1):9-15. PubMed PMID: 2838304.
2: Holck M, Osterrieder W. Inhibition of myocardial Ca2+ channels by three dihydropyridines with different structural features: potential-dependent blockade by Ro 18-3981. Br J Pharmacol. 1987 May;91(1):61-7. PubMed PMID: 2439160; PubMed Central PMCID: PMC1853498.