WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526185
CAS#: 77273-77-9
Description: Ro 31-0313 is a metabolite of Ro 03-8799, radiation sensitizing agent.
Hodoodo Cat#: H526185
Name: Ro 31-0313
CAS#: 77273-77-9
Chemical Formula: C11H18N4O4
Exact Mass: 270.13
Molecular Weight: 270.290
Elemental Analysis: C, 48.88; H, 6.71; N, 20.73; O, 23.68
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Synonym: Ro 31-0313; Ro 310313; Ro-31-0313.
IUPAC/Chemical Name: 2-Nitro-alpha-piperidinomethyl-1-imidazole ethanol N-oxide
InChi Key: BZKCKUMYSBPPIC-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H18N4O4/c1-11(16,9-12-5-3-2-4-6-12)13-7-8-14(17)10(13)15(18)19/h7-8,16H,2-6,9H2,1H3
SMILES Code: CC(N1C=C[N+]([O-])=C1[N+]([O-])=O)(CN2CCCCC2)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 270.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Walton MI, Bleehen NM, Workman P. Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice. Br J Cancer. 1989 May;59(5):667-73. PubMed PMID: 2736198; PubMed Central PMCID: PMC2247237.
2: Walton MI, Bleehen NM, Workman P. The effects of whole body hyperthermia on the pharmacokinetics and toxicity of the basic 2-nitroimidazole radiosensitizer Ro 03-8799 in mice. Br J Cancer. 1987 May;55(5):469-76. PubMed PMID: 3606940; PubMed Central PMCID: PMC2001726.
3: Malcolm SL, Lee A, Groves JK. High-performance liquid chromatographic analysis of the new hypoxic cell radiosensitiser, Ro 03-8799, in biological samples. J Chromatogr. 1983 Apr 8;273(2):327-33. PubMed PMID: 6863447.