WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526186
CAS#: 86941-24-4
Description: Ro 31-1118 is a beta-adrenoceptor partial agonist.
Hodoodo Cat#: H526186
Name: Ro 31-1118
CAS#: 86941-24-4
Chemical Formula: C22H30FNO4
Exact Mass: 391.22
Molecular Weight: 391.480
Elemental Analysis: C, 67.50; H, 7.72; F, 4.85; N, 3.58; O, 16.35
This product is not in stock, which may be available by custom synthesis.
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Synonym: Ro 31-1118; Ro 311118; Ro-31-1118.
IUPAC/Chemical Name: 2-Propanol, 1-(4-(2-(2-(4-fluorophenyl)ethoxy)ethoxy)phenoxy)-3-((1-methylethyl)amino)-, (+-)-
InChi Key: CYCXZGUVPDRYLG-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H30FNO4/c1-17(2)24-15-20(25)16-28-22-9-7-21(8-10-22)27-14-13-26-12-11-18-3-5-19(23)6-4-18/h3-10,17,20,24-25H,11-16H2,1-2H3
SMILES Code: OC(CNC(C)C)COC1=CC=C(OCCOCCC2=CC=C(F)C=C2)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 391.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sysoliatina NA. [The effect of propranolol and flusoxolol on the lysosomal enzyme activity of the rat ventricular myocardium]. Eksp Klin Farmakol. 1992 Sep-Oct;55(5):33-6. Russian. PubMed PMID: 1363945.
2: McCaffrey PM, Riddell JG, Shanks RG. An assessment of the partial agonist activity of Ro 31-1118, flusoxolol and pindolol in man. Br J Clin Pharmacol. 1987 Nov;24(5):571-80. PubMed PMID: 2893634; PubMed Central PMCID: PMC1386328.
3: Gillies HC, Rogers HJ, Francis RJ, Galloway DB, Humphreys JE. Pharmacokinetics of single and multiple doses of flusoxolol (Ro 31-1411) in healthy subjects. Eur J Clin Pharmacol. 1986;31(1):113-5. PubMed PMID: 2877883.
4: O'Connor PC, Arnold JM, Brown AN, Francis RJ, Finch MB, Galloway DB, Harron DW, McDevitt DG, Shanks RG. Human pharmacokinetic and pharmacodynamic studies on Ro31-1118, a new beta-adrenoceptor antagonist. Br J Clin Pharmacol. 1985 Mar;19(3):319-27. PubMed PMID: 2859047; PubMed Central PMCID: PMC1463730.
5: Jamieson M, Petrie JC, Webster J, Miller A, Harris RI, Francis RJ. Ro 31-1118, a new cardioselective beta-adrenoceptor antagonist. Pharmacokinetics and effects on heart rate and blood pressure in mild hypertensives. Eur J Clin Pharmacol. 1985;29(4):395-9. PubMed PMID: 2868899.
