WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H328073
CAS#: 447406-78-2
Description: Sodelglitazar, also known as GSK-677954, is a PPAR agonist potentially for the treatment of hyperlipidemia and type 2 diabetes.
Hodoodo Cat#: H328073
Name: Sodelglitazar
CAS#: 447406-78-2
Chemical Formula: C23H21F4NO3S2
Exact Mass: 499.09
Molecular Weight: 499.539
Elemental Analysis: C, 55.30; H, 4.24; F, 15.21; N, 2.80; O, 9.61; S, 12.84
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Synonym: Sodelglitazar; GSK-677954; GW677954.
IUPAC/Chemical Name: 2-(4-(((2-(2-Fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)-2-methylpropanoic acid
InChi Key: ZUGQWAYOWCBWGM-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H21F4NO3S2/c1-12-9-15(6-8-18(12)31-22(3,4)21(29)30)32-11-19-13(2)28-20(33-19)16-7-5-14(10-17(16)24)23(25,26)27/h5-10H,11H2,1-4H3,(H,29,30)
SMILES Code: CC(C)(OC1=CC=C(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3F)S2)C=C1C)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 499.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Liu XY, Wang RL, Xu WR, Tang LD, Wang SQ, Chou KC. Docking and molecular
dynamics simulations of peroxisome proliferator activated receptors interacting
with pan agonist sodelglitazar. Protein Pept Lett. 2011 Oct;18(10):1021-7. PubMed
PMID: 21592078.