WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526999
CAS#: 719272-79-4 (free base)
Description: MK-0736 is a potent and selective 11β-HSD-1 inhibitor. Emerging data from animal and human studies indicate an association of 11β-HSD1 over-expression with obesity and disorders in glucose and lipid metabolism. This has led to the hypothesis that selective inhibition of 11β-HSD1 could be used to treat MetS and diabetes 11beta-Hydroxysteroid dehydrogenase type 1 inhibitors are novel agents for the treatment of metabolic syndrome and obesity-related disorders.
Hodoodo Cat#: H526999
Name: MK-0736
CAS#: 719272-79-4 (free base)
Chemical Formula: C23H30F3N3O2S
Exact Mass: 469.20
Molecular Weight: 469.567
Elemental Analysis: C, 58.83; H, 6.44; F, 12.14; N, 8.95; O, 6.81; S, 6.83
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Related CAS #: 719272-79-4 (free base) 719274-77-8 (HCl) 1228883-16-6 (methanol) 1228883-17-7 (ethanol)
Synonym: MK-0736; MK 0736; MK0736.
IUPAC/Chemical Name: 3-(4-(3-(ethylsulfonyl)propyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
InChi Key: ORQZQBUNAMJFCY-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H30F3N3O2S/c1-3-32(30,31)16-6-9-21-10-13-22(14-11-21,15-12-21)20-28-27-19(29(20)2)17-7-4-5-8-18(17)23(24,25)26/h4-5,7-8H,3,6,9-16H2,1-2H3
SMILES Code: CCS(CCCC1(CC2)CCC2(C3=NN=C(C4=CC=CC=C4C(F)(F)F)N3C)CC1)(=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# 719272-79-4 (MK-0736 free base) 719274-77-8 (MK-0736 hydrochloride)
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 469.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Anagnostis P, Katsiki N, Adamidou F, Athyros VG, Karagiannis A, Kita M,
Mikhailidis DP. 11beta-Hydroxysteroid dehydrogenase type 1 inhibitors: novel
agents for the treatment of metabolic syndrome and obesity-related disorders?
Metabolism. 2013 Jan;62(1):21-33. doi: 10.1016/j.metabol.2012.05.002. Review.
PubMed PMID: 22652056.
2: Shah S, Hermanowski-Vosatka A, Gibson K, Ruck RA, Jia G, Zhang J, Hwang PM,
Ryan NW, Langdon RB, Feig PU. Efficacy and safety of the selective 11β-HSD-1
inhibitors MK-0736 and MK-0916 in overweight and obese patients with
hypertension. J Am Soc Hypertens. 2011 May-Jun;5(3):166-76. doi:
10.1016/j.jash.2011.01.009. PubMed PMID: 21419745.
3: Veryard C. American Society for Clinical Pharmacology and Therapeutics
(ASCPT)-111th annual meeting. 17-20 March 2010, Atlanta, GA, USA. IDrugs. 2010
May;13(5):286-8. PubMed PMID: 20432179.