Farampator
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Hodoodo CAT#: H328099

CAS#: 211735-76-1

Description: Farampator, also known as Org-24448; CX-691, is an AMPA receptor positive allosteric modulator potentially for the treatment of schizophrenia.


Chemical Structure

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Farampator
CAS# 211735-76-1

Theoretical Analysis

Hodoodo Cat#: H328099
Name: Farampator
CAS#: 211735-76-1
Chemical Formula: C12H13N3O2
Exact Mass: 231.10
Molecular Weight: 231.255
Elemental Analysis: C, 62.33; H, 5.67; N, 18.17; O, 13.84

Price and Availability

Size Price Availability Quantity
100mg USD 450 2 weeks
200mg USD 750 2 weeks
500mg USD 1550 2 weeks
1g USD 2850 2 weeks
2g USD 4650 2 weeks
5g USD 6750 2 weeks
Bulk inquiry

Synonym: Farampator; Org-24448; CX-691; Org24448; CX691.

IUPAC/Chemical Name: 1-(2,1,3-Benzoxadiazol-5-ylcarbonyl)piperidine

InChi Key: XFVRBYKKGGDPAJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H13N3O2/c16-12(15-6-2-1-3-7-15)9-4-5-10-11(8-9)14-17-13-10/h4-5,8H,1-3,6-7H2

SMILES Code: O=C(N1CCCCC1)C2=CC3=NON=C3C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 231.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jardemark K, Marcus MM, Malmerfelt A, Shahid M, Svensson TH. Differential
effects of AMPA receptor potentiators and glycine reuptake inhibitors on
antipsychotic efficacy and prefrontal glutamatergic transmission.
Psychopharmacology (Berl). 2012 May;221(1):115-31. doi:
10.1007/s00213-011-2554-3. PubMed PMID: 22068461.


2: Woolley ML, Waters KA, Gartlon JE, Lacroix LP, Jennings C, Shaughnessy F, Ong
A, Pemberton DJ, Harries MH, Southam E, Jones DN, Dawson LA. Evaluation of the
pro-cognitive effects of the AMPA receptor positive modulator,
5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat.
Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54. doi:
10.1007/s00213-008-1325-2. PubMed PMID: 18795266.


3: Dawson N, Ferrington L, Olverman HJ, Kelly PA. Novel analysis for improved
validity in semi-quantitative 2-deoxyglucose autoradiographic imaging. J Neurosci
Methods. 2008 Oct 30;175(1):25-35. doi: 10.1016/j.jneumeth.2008.07.020. PubMed
PMID: 18762213.


4: Wezenberg E, Verkes RJ, Ruigt GS, Hulstijn W, Sabbe BG. Acute effects of the
ampakine farampator on memory and information processing in healthy elderly
volunteers. Neuropsychopharmacology. 2007 Jun;32(6):1272-83. PubMed PMID:
17119538.


5: Jordan GR, McCulloch J, Shahid M, Hill DR, Henry B, Horsburgh K. Regionally
selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on
local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose
autoradiography. Neuropharmacology. 2005 Aug;49(2):254-64. PubMed PMID: 15993447.