WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H328100
CAS#: 178040-94-3
Description: Opaviraline, also known as GW-420867X; GW-867; HBY-1293, is a reverse transcriptase inhibitor potentially for the treatment of HIV infection.
Hodoodo Cat#: H328100
Name: Opaviraline
CAS#: 178040-94-3
Chemical Formula: C14H17FN2O3
Exact Mass: 280.12
Molecular Weight: 280.299
Elemental Analysis: C, 59.99; H, 6.11; F, 6.78; N, 9.99; O, 17.12
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Synonym: Opaviraline; GW-420867X; GW-867; HBY-1293; GW420867X; GW867; HBY1293.
IUPAC/Chemical Name: isopropyl (S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxaline-1(2H)-carboxylate
InChi Key: KELNNWMENBUHNS-NSHDSACASA-N
InChi Code: InChI=1S/C14H17FN2O3/c1-4-11-13(18)16-10-6-5-9(15)7-12(10)17(11)14(19)20-8(2)3/h5-8,11H,4H2,1-3H3,(H,16,18)/t11-/m0/s1
SMILES Code: O=C(N1[C@@H](CC)C(NC2=C1C=C(F)C=C2)=O)OC(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 280.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Mori K, Yasutomi Y, Sawada S, Villinger F, Sugama K, Rosenwith B, Heeney JL,
Uberla K, Yamazaki S, Ansari AA, Rübsamen-Waigmann H. Suppression of acute
viremia by short-term postexposure prophylaxis of simian/human immunodeficiency
virus SHIV-RT-infected monkeys with a novel reverse transcriptase inhibitor
(GW420867) allows for development of potent antiviral immune responses resulting
in efficient containment of infection. J Virol. 2000 Jul;74(13):5747-53. PubMed
PMID: 10846052; PubMed Central PMCID: PMC112067.