RS-1
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Hodoodo CAT#: H406955

CAS#: 312756-74-4

Description: RS-1, also known as RAD51-Stimulatory Compound-1, a RAD51 activator with potential anticancer activity. RAD51 is the central protein that catalyzes DNA repair via homologous recombination, a process that ensures genomic stability. RAD51 protein is commonly expressed at high levels in cancer cells relative to their noncancerous precursors. High levels of RAD51 expression can lead to the formation of genotoxic RAD51 protein complexes on undamaged chromatin.

Chemical Structure

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RS-1
CAS# 312756-74-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H406955
Name: RS-1
CAS#: 312756-74-4
Chemical Formula: C20H16Br2N2O3S
Exact Mass: 521.92
Molecular Weight: 524.230
Elemental Analysis: C, 45.82; H, 3.08; Br, 30.48; N, 5.34; O, 9.16; S, 6.12

Price and Availability

Size Price Availability Quantity
5g USD -1 2 Weeks
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1450 2 Weeks
1g USD 2250 2 Weeks
2g USD 3850 2 Weeks
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Synonym: RS-1; RS 1; RS1. RAD51-Stimulatory Compound-1.

IUPAC/Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide

InChi Key: SWKAVEUTKGKHSR-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)

SMILES Code: O=C(NC1=CC=C(Br)C=C1)C2=CC=C(Br)C(S(=O)(NCC3=CC=CC=C3)=O)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO and DMF

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 524.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mason JM, Logan HL, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski
AP, Bishop DK, Connell PP. The RAD51-stimulatory compound RS-1 can exploit the
RAD51 overexpression that exists in cancer cells and tumors. Cancer Res. 2014 Jul
1;74(13):3546-55. doi: 10.1158/0008-5472.CAN-13-3220. PubMed PMID: 24753542;
PubMed Central PMCID: PMC4079730.