Z944
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Hodoodo CAT#: H530318

CAS#: 1199236-64-0 (free base)

Description: Z944 is a T-type calcium channel antagonist potentially for the treatment of pain. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg. Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain. Z944 Delays the Progression of Seizures in the Amygdala Kindling Model.


Chemical Structure

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Z944
CAS# 1199236-64-0 (free base)

Theoretical Analysis

Hodoodo Cat#: H530318
Name: Z944
CAS#: 1199236-64-0 (free base)
Chemical Formula: C19H27ClFN3O2
Exact Mass: 383.18
Molecular Weight: 383.892
Elemental Analysis: C, 59.45; H, 7.09; Cl, 9.23; F, 4.95; N, 10.95; O, 8.34

Price and Availability

Size Price Availability Quantity
5mg USD 350 2 Weeks
10mg USD 550 2 Weeks
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Related CAS #: 1199236-64-0 (free base)   1797986-84-5 (HCl)  

Synonym: Z-944; Z 944; Z944; Ulixacaltamide;

IUPAC/Chemical Name: N-[[1-[2-(tert-butylamino)-2-oxoethyl]piperidin-4-yl]methyl]-3-chloro-5-fluorobenzamide

InChi Key: JOCLITFYIMJMNK-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H27ClFN3O2/c1-19(2,3)23-17(25)12-24-6-4-13(5-7-24)11-22-18(26)14-8-15(20)10-16(21)9-14/h8-10,13H,4-7,11-12H2,1-3H3,(H,22,26)(H,23,25)

SMILES Code: O=C(NCC1CCN(CC(NC(C)(C)C)=O)CC1)C2=CC(F)=CC(Cl)=C2

Appearance: White to off-white solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 383.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Marks WN, Greba Q, Cain SM, Snutch TP, Howland JG. The T-type calcium channel antagonist Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. Neuroscience. 2016 Sep 22;332:121-9. doi: 10.1016/j.neuroscience.2016.06.035. PubMed PMID: 27365170.

2: Marks WN, Cain SM, Snutch TP, Howland JG. The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg. Neurobiol Dis. 2016 Oct;94:106-15. doi: 10.1016/j.nbd.2016.06.001. PubMed PMID: 27282256.

3: LeBlanc BW, Lii TR, Huang JJ, Chao YC, Bowary PM, Cross BS, Lee MS, Vera-Portocarrero LP, Saab CY. T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain. Pain. 2016 Jan;157(1):255-63. doi: 10.1097/j.pain.0000000000000362. PubMed PMID: 26683108.

4: Matschke LA, Bertoune M, Roeper J, Snutch TP, Oertel WH, Rinné S, Decher N. A concerted action of L- and T-type Ca(2+) channels regulates locus coeruleus pacemaking. Mol Cell Neurosci. 2015 Sep;68:293-302. doi: 10.1016/j.mcn.2015.08.012. PubMed PMID: 26319746.

5: Casillas-Espinosa PM, Hicks A, Jeffreys A, Snutch TP, O'Brien TJ, Powell KL. Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model. PLoS One. 2015 Aug 14;10(8):e0130012. doi: 10.1371/journal.pone.0130012. PubMed PMID: 26274319; PubMed Central PMCID: PMC4537250.

6: Lee M. Z944: a first in class T-type calcium channel modulator for the treatment of pain. J Peripher Nerv Syst. 2014 Oct;19 Suppl 2:S11-2. doi: 10.1111/jns.12080_2. PubMed PMID: 25269728.

7: Ranzato E, Magnelli V, Martinotti S, Waheed Z, Cain SM, Snutch TP, Marchetti C, Burlando B. Epigallocatechin-3-gallate elicits Ca2+ spike in MCF-7 breast cancer cells: essential role of Cav3.2 channels. Cell Calcium. 2014 Oct;56(4):285-95. doi: 10.1016/j.ceca.2014.09.002. PubMed PMID: 25260713.

8: Cain SM, Tyson JR, Jones KL, Snutch TP. Thalamocortical neurons display suppressed burst-firing due to an enhanced Ih current in a genetic model of absence epilepsy. Pflugers Arch. 2015 Jun;467(6):1367-82. doi: 10.1007/s00424-014-1549-4. PubMed PMID: 24953239; PubMed Central PMCID: PMC4435665.

9: Tringham E, Powell KL, Cain SM, Kuplast K, Mezeyova J, Weerapura M, Eduljee C, Jiang X, Smith P, Morrison JL, Jones NC, Braine E, Rind G, Fee-Maki M, Parker D, Pajouhesh H, Parmar M, O'Brien TJ, Snutch TP. T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci Transl Med. 2012 Feb 15;4(121):121ra19. doi: 10.1126/scitranslmed.3003120. PubMed PMID: 22344687.