WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530333
CAS#: 70842-04-5
Description: RO13-3978 is a broad-spectrum antischistosomal. Ro 13-3978 showed minor in vitro activity and no damage to the tegument was found. No cytotoxicity was detected for Ro 13-3978. Ro 13-3978 was metabolically stable. Ro 13-3978 has excellent antischistosomal properties in vivo.
Hodoodo Cat#: H530333
Name: Ro 13-3978
CAS#: 70842-04-5
Chemical Formula: C12H10F4N2O2
Exact Mass: 290.07
Molecular Weight: 290.218
Elemental Analysis: C, 49.66; H, 3.47; F, 26.19; N, 9.65; O, 11.03
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Synonym: Ro 13-3978; Ro13-3978; Ro-13-3978; Ro 133978; Ro133978; Ro-133978.
IUPAC/Chemical Name: 3-(4-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione
InChi Key: BTGSGTWRNQCEQY-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H10F4N2O2/c1-11(2)9(19)18(10(20)17-11)6-3-4-8(13)7(5-6)12(14,15)16/h3-5H,1-2H3,(H,17,20)
SMILES Code: FC1=C(C(F)(F)F)C=C(N2C(C(C)(C)NC2=O)=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 290.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Keiser J, Panic G, Vargas M, Wang C, Dong Y, Gautam N, Vennerstrom JL. Aryl
hydantoin Ro 13-3978, a broad-spectrum antischistosomal. J Antimicrob Chemother.
2015;70(6):1788-97. doi: 10.1093/jac/dkv016. PubMed PMID: 25691324; PubMed
Central PMCID: PMC4462663.
2: Wang C, Zhao Q, Min J, Muniyan S, Vargas M, Wang X, Dong Y, Guy RK, Lin MF,
Keiser J, Vennerstrom JL. Antischistosomal versus antiandrogenic properties of
aryl hydantoin Ro 13-3978. Am J Trop Med Hyg. 2014 Jun;90(6):1156-8. doi:
10.4269/ajtmh.14-0029. PubMed PMID: 24686741; PubMed Central PMCID: PMC4047746.
3: Forget E, Félix H, Notteghem MJ, Léger N. [Efficacy of schistosomicide
derivatives, appreciation with electronic microscopy experimental model (author's
transl)]. Bull Soc Pathol Exot Filiales. 1982 Mar-Apr;75(2):192-200. French.
PubMed PMID: 6809349.
