WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530349
CAS#: 178419-42-6 (HCl)
Description: AR-R17779 is a selective alpha7 nicotinic agonist (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). AR-R17779 improves learning and memory in rats. Treatment with AR-R17779 significantly reduced atherosclerotic plaque area and improved survival of mice. Treatment with AR-R17779 also suppressed abdominal aortic aneurysm formation. Quantitative RT-PCR of the aorta revealed that mRNA expression levels of interleukin-1β, interleukin-6 and NOX2 were significantly decreased in AR-R17779-treated mice compared with Ang II+HFD mice. AR-R17779 treatment also reduced blood pressure and serum lipid levels.
Hodoodo Cat#: H530349
Name: AR-R17779 HCl
CAS#: 178419-42-6 (HCl)
Chemical Formula: C9H15ClN2O2
Exact Mass: 0.00
Molecular Weight: 218.681
Elemental Analysis: C, 49.43; H, 6.91; Cl, 16.21; N, 12.81; O, 14.63
Related CAS #: 178419-42-6 (HCl) 178419-47-1 (free base)
Synonym: AR-R17779 hydrochloride; AR-R17779; AR-R-17779; AR-R 17779.
IUPAC/Chemical Name: (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride
InChi Key: XGLBLUBBDSJBIU-FVGYRXGTSA-N
InChi Code: InChI=1S/C9H14N2O2.ClH/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11;/h7H,1-6H2,(H,10,12);1H/t9-;/m0./s1
SMILES Code: O=C(NC1)O[C@@]21CN3CCC2CC3.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# CAS#178419-42-6 (AR-R17779 hydrochloride) CAS#178419-47-1 (AR-R17779 free base)
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The following data is based on the product molecular weight 218.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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