WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H531307
CAS#: 315702-99-9
Description: STF-62247 is a potent autophagy inducer. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).
Hodoodo Cat#: H531307
Name: STF-62247
CAS#: 315702-99-9
Chemical Formula: C15H13N3S
Exact Mass: 267.08
Molecular Weight: 267.350
Elemental Analysis: C, 67.39; H, 4.90; N, 15.72; S, 11.99
Synonym: STF-62247; STF 62247; STF62247; STF-062247; STF 062247; STF062247;
IUPAC/Chemical Name: 4-(pyridin-4-yl)-N-m-tolylthiazol-2-amine
InChi Key: KATNUHQNJGNLPW-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
SMILES Code: CC1=CC(NC2=NC(C3=CC=NC=C3)=CS2)=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 267.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Aparicio IM, Martin Muñoz P, Salido GM, Peña FJ, Tapia JA. The autophagy-related protein LC3 is processed in stallion spermatozoa during short-and long-term storage and the related stressful conditions. Animal. 2016 Jul;10(7):1182-91. doi: 10.1017/S1751731116000240. PubMed PMID: 26932581.
2: Anbalagan S, Pires IM, Blick C, Hill MA, Ferguson DJ, Chan DA, Hammond EM. Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiother Oncol. 2012 Jun;103(3):388-93. doi: 10.1016/j.radonc.2012.04.001. PubMed PMID: 22551566.
3: Zimmerman BE, Palm S. Results of an international comparison of 57Co. Appl Radiat Isot. 2010 Jul-Aug;68(7-8):1217-20. doi: 10.1016/j.apradiso.2009.12.021. PubMed PMID: 20071188.
4: Chan DA, Giaccia AJ. Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle. 2008 Oct;7(19):2987-90. Review. PubMed PMID: 18818511.
5: Turcotte S, Sutphin PD, Giaccia AJ. Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death. Autophagy. 2008 Oct;4(7):944-6. PubMed PMID: 18769110; PubMed Central PMCID: PMC2803726.
6: Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 2008 Jul 8;14(1):90-102. doi: 10.1016/j.ccr.2008.06.004. PubMed PMID: 18598947; PubMed Central PMCID: PMC2819422.
