KP-1212

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H558211

CAS#: 114522-16-6

Description: KP-1212, also known as SN-1212, is a nucleoside designed for the treatment of HIV by viral mutagenesis.

Chemical Structure

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KP-1212
CAS# 114522-16-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H558211
Name: KP-1212
CAS#: 114522-16-6
Chemical Formula: C8H14N4O4
Exact Mass: 230.10
Molecular Weight: 230.224
Elemental Analysis: C, 41.74; H, 6.13; N, 24.34; O, 27.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SN-1212; KP-1212; SN1212; KP1212; SN 1212; KP 1212

IUPAC/Chemical Name: 2'-Deoxy-5,6-dihydro-5-azacytidine

InChi Key: LAOLDMMWVYDDID-KVQBGUIXSA-N

InChi Code: InChI=1S/C8H14N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h4-6,13-14H,1-3H2,(H3,9,10,11,15)/t4-,5+,6+/m0/s1

SMILES Code: OC[C@@H]1[C@H](C[C@H](N2C(N=C(NC2)N)=O)O1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 230.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rawson JM, Heineman RH, Beach LB, Martin JL, Schnettler EK, Dapp MJ, Patterson SE, Mansky LM. 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. Bioorg Med Chem. 2013 Nov 15;21(22):7222-8. doi: 10.1016/j.bmc.2013.08.023. PubMed PMID: 24120088; PubMed Central PMCID: PMC3930610.

2: Harris KS, Brabant W, Styrchak S, Gall A, Daifuku R. KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. Antiviral Res. 2005 Jul;67(1):1-9. PubMed PMID: 15890415.

3: Clay PG, McRae M, Laurent JP. Safety, Tolerability, and Pharmacokinetics of KP-1461 in Phase I Clinical Studies: A Single Oral Dose Study in Non-HIV-Infected Adults, and a 14-Day Dose-Escalating Study in Highly Antiretroviral-Experienced HIV-Infected Adults. J Int Assoc Physicians AIDS Care (Chic). 2011 Jul-Aug;10(4):232-8. doi: 10.1177/1545109711406442. PubMed PMID: 21593403.

4: Peng CS, Fedeles BI, Singh V, Li D, Amariuta T, Essigmann JM, Tokmakoff A. Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3229-34. doi: 10.1073/pnas.1415974112. PubMed PMID: 25733867; PubMed Central PMCID: PMC4371980.

5: Murakami E, Basavapathruni A, Bradley WD, Anderson KS. Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases. Antiviral Res. 2005 Jul;67(1):10-7. PubMed PMID: 15950748.

6: Li D, Fedeles BI, Singh V, Peng CS, Silvestre KJ, Simi AK, Simpson JH, Tokmakoff A, Essigmann JM. Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3252-9. doi: 10.1073/pnas.1405635111. PubMed PMID: 25071207; PubMed Central PMCID: PMC4136561.

7: Matoušová M, Votruba I, Otmar M, Tloušťová E, Günterová J, Mertlíková-Kaiserová H. 2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential. Epigenetics. 2011 Jun;6(6):769-76. PubMed PMID: 21566456; PubMed Central PMCID: PMC3142367.