WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526372
CAS#: 69388-79-0 (pivoxil)
Description: Sulbactam pivoxil, also known as CP-47904 and Pivsulbactam, is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic. Sulbactam pivoxil has a better absorption than the parent agent and provides high serum levels after oral administration.
Hodoodo Cat#: H526372
Name: Sulbactam pivoxil
CAS#: 69388-79-0 (pivoxil)
Chemical Formula: C14H21NO7S
Exact Mass: 347.10
Molecular Weight: 347.380
Elemental Analysis: C, 48.41; H, 6.09; N, 4.03; O, 32.24; S, 9.23
Related CAS #: 69388-84-7 (Na+) 69388-79-0 (pivoxil) 68373-14-8 (free acid)
Synonym: CP-47,904; CP47,904; CP 47,904; CP-47904; CP47904; CP 47904; Sulbactam pivoxil; Pivsulbactam.
IUPAC/Chemical Name: (pivaloyloxy)methyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
InChi Key: OHPVYKXTRACOSQ-ZJUUUORDSA-N
InChi Code: InChI=1S/C14H21NO7S/c1-13(2,3)12(18)22-7-21-11(17)10-14(4,5)23(19,20)9-6-8(16)15(9)10/h9-10H,6-7H2,1-5H3/t9-,10+/m1/s1
SMILES Code: O=C([C@@H](C(C)(C)S([C@]1([H])C2)(=O)=O)N1C2=O)OCOC(C(C)(C)C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Soluble in DMSO | 0.0 | 100.00 |
The following data is based on the product molecular weight 347.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Changov LS, Vassileva BK, Confino MN, Agapova NN. An efficient method for the synthesis of sulbactam pivoxil. Farmaco. 2000 Feb;55(2):134-5. PubMed PMID: 10782385.
2: Davies BI, Maesen FP, Jevons S, Brouwers J. Combination of sulbactam pivoxyl and bacampicillin in acute exacerbations of chronic bronchitis. J Antimicrob Chemother. 1982 Nov;10(5):445-52. PubMed PMID: 6294045.
3: Pei Q, Yang GP, Li ZJ, Peng XD, Fan JH, Liu ZQ. Simultaneous analysis of amoxicillin and sulbactam in human plasma by HPLC-DAD for assessment of bioequivalence. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jul 1;879(21):2000-4. doi: 10.1016/j.jchromb.2011.05.021. PubMed PMID: 21680260.
4: Abdenur JE, Chamoles NA, Guinle AE, Schenone AB, Fuertes AN. Diagnosis of isovaleric acidaemia by tandem mass spectrometry: false positive result due to pivaloylcarnitine in a newborn screening programme. J Inherit Metab Dis. 1998 Aug;21(6):624-30. PubMed PMID: 9762597.
5: Sjövall J, Huitfeldt B, Magni L, Nord CE. Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84. Review. PubMed PMID: 3547627.
6: English AR, Girard D, Jasys VJ, Martingano RJ, Kellogg MS. Orally effective acid prodrugs of the beta-lactamase inhibitor sulbactam. J Med Chem. 1990 Jan;33(1):344-7. PubMed PMID: 2296030.
