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Sulbactam
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H526371

CAS#: 68373-14-8 (free acid)

Description: Sulbactam, also known as CP 45899, is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics. Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.Sulbactam is able to inhibit the most common forms of β-lactamase but is not able to interact with the AmpC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.

Chemical Structure

Sulbactam

CAS# 68373-14-8 (free acid)

Instruction

Theoretical Analysis

Hodoodo Cat#: H526371
Name: Sulbactam
CAS#: 68373-14-8 (free acid)
Chemical Formula: C8H11NO5S
Exact Mass: 233.04
Molecular Weight: 233.238
Elemental Analysis: C, 41.20; H, 4.75; N, 6.01; O, 34.30; S, 13.75

Price and Availability

Size	Price	Availability
1g	USD 350	2 Weeks
2g	USD 550	2 Weeks
5g	USD 950	2 Weeks
10g	USD 1650	2 Weeks
20g	USD 2950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: CP-45899; CP 45899; CP45899; CP-45,899; CP 45,899; CP45,899; Sulbactam

IUPAC/Chemical Name: (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide

InChi Key: FKENQMMABCRJMK-RITPCOANSA-N

InChi Code: InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1

SMILES Code: O=C([C@@H](C(C)(C)S([C@]1([H])C2)(=O)=O)N1C2=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 68373-14-8 (Sulbactam) 69388-84-7 (Sulbactam sodium)

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	Soluble in DMSO	0.0	100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 233.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Chu H, Zhao L, Wang M, Liu Y, Gui T, Zhang J. Sulbactam-based therapy for Acinetobacter baumannii infection: a systematic review and meta-analysis. Braz J Infect Dis. 2013 Jul-Aug;17(4):389-94. doi: 10.1016/j.bjid.2012.10.029. Review. PubMed PMID: 23602463.

2: Adnan S, Paterson DL, Lipman J, Roberts JA. Ampicillin/sulbactam: its potential use in treating infections in critically ill patients. Int J Antimicrob Agents. 2013 Nov;42(5):384-9. doi: 10.1016/j.ijantimicag.2013.07.012. Review. PubMed PMID: 24041466.

3: Betrosian AP, Douzinas EE. Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. Expert Opin Drug Metab Toxicol. 2009 Sep;5(9):1099-112. doi: 10.1517/17425250903145251. Review. PubMed PMID: 19621991.

4: Akova M. Sulbactam-containing beta-lactamase inhibitor combinations. Clin Microbiol Infect. 2008 Jan;14 Suppl 1:185-8. Review. Erratum in: Clin Microbiol Infect. 2008 May;14 Suppl 5:21-4. PubMed PMID: 18154545.

5: Lode HM. Rational antibiotic therapy and the position of ampicillin/sulbactam. Int J Antimicrob Agents. 2008 Jul;32(1):10-28. doi: 10.1016/j.ijantimicag.2008.02.004. Review. PubMed PMID: 18539004.

6: Rafailidis PI, Ioannidou EN, Falagas ME. Ampicillin/sulbactam: current status in severe bacterial infections. Drugs. 2007;67(13):1829-49. Review. PubMed PMID: 17722953.

7: Herych ID, Vashchuk VV. [Modern possibilities of hepacef combi (cefoperazon/sulbactam) application for the treatment of surgical infection]. Klin Khir. 2011 Feb;(2):65-9. Review. Ukrainian. PubMed PMID: 21548334.

8: Barcelona L, Marín M, Stamboulian D. [Betalactam antibiotics combined with bectalactamases inhibitors. Amoxicillin-sulbactam]. Medicina (B Aires). 2008;68(1):65-74. Review. Spanish. PubMed PMID: 18416324.

9: Levin AS. Multiresistant Acinetobacter infections: a role for sulbactam combinations in overcoming an emerging worldwide problem. Clin Microbiol Infect. 2002 Mar;8(3):144-53. Review. PubMed PMID: 12010169.

10: Soutric J, Bantar C, Caruso N, Heguilén R, Casellas JM Jr, Casellas JM, Farinati A, Jasovich A, Arenoso H, Rodriguez M. Review of pharmacokinetic, pharmacodynamic and clinical studies with a modern combination of amoxicillin/sulbactam. Chemotherapy. 2006;52(4):200-4. Review. PubMed PMID: 16720984.

11: Kanra G. Experience with ampicillin/sulbactam in severe infections. J Int Med Res. 2002;30 Suppl 1:20A-30A. Review. PubMed PMID: 11921491.

12: Dajani A. Use of ampicillin/sulbactam and sultamicillin in pediatric infections: a re-evaluation. J Int Med Res. 2001 Jul-Aug;29(4):257-69. Review. PubMed PMID: 11675898.

13: Singh GS. Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam. Mini Rev Med Chem. 2004 Jan;4(1):93-109. Review. PubMed PMID: 14754446.

14: Lode H. Role of sultamicillin and ampicillin/sulbactam in the treatment of upper and lower bacterial respiratory tract infections. Int J Antimicrob Agents. 2001 Sep;18(3):199-209. Review. PubMed PMID: 11673031.

15: Williams JD. beta-Lactamase inhibition and in vitro activity of sulbactam and sulbactam/cefoperazone. Clin Infect Dis. 1997 Mar;24(3):494-7. Review. PubMed PMID: 9114205.

16: Garnacho-Montero J, Amaya-Villar R, Ferrándiz-Millón C, Díaz-Martín A, López-Sánchez JM, Gutiérrez-Pizarraya A. Optimum treatment strategies for carbapenem-resistant Acinetobacter baumannii bacteremia. Expert Rev Anti Infect Ther. 2015 Jun;13(6):769-77. doi: 10.1586/14787210.2015.1032254. Review. PubMed PMID: 25865094.

17: Chapman E, Reveiz L, Illanes E, Bonfill Cosp X. Antibiotic regimens for management of intra-amniotic infection. Cochrane Database Syst Rev. 2014 Dec 19;(12):CD010976. doi: 10.1002/14651858.CD010976.pub2. Review. PubMed PMID: 25526426.

18: Siriwachirachai T, Sangkomkamhang US, Lumbiganon P, Laopaiboon M. Antibiotics for meconium-stained amniotic fluid in labour for preventing maternal and neonatal infections. Cochrane Database Syst Rev. 2014 Nov 6;(11):CD007772. doi: 10.1002/14651858.CD007772.pub3. Review. PubMed PMID: 25374369.

19: Shakil S, Azhar EI, Tabrez S, Kamal MA, Jabir NR, Abuzenadah AM, Damanhouri GA, Alam Q. New Delhi metallo-β-lactamase (NDM-1): an update. J Chemother. 2011 Oct;23(5):263-5. Review. PubMed PMID: 22005056.

20: Alpuche-Aranda CM. Beta-lactamase production and the role of ampicillin/sulbactam. Pediatr Infect Dis J. 1998 Mar;17(3 Suppl):S8-11; discussion S20-1. Review. PubMed PMID: 9519908.

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