P552-02 free base
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H530110

CAS#: 587879-32-1 (free base)

Description: P552-02, also known as KM-003, PS 552-02, or 552-02, is a sodium channel blocker potentially for the treatment of cystic fibrosis.


Chemical Structure

img
P552-02 free base
CAS# 587879-32-1 (free base)

Theoretical Analysis

Hodoodo Cat#: H530110
Name: P552-02 free base
CAS#: 587879-32-1 (free base)
Chemical Formula: C19H26ClN7O4
Exact Mass: 451.17
Molecular Weight: 451.912
Elemental Analysis: C, 50.50; H, 5.80; Cl, 7.84; N, 21.70; O, 14.16

Price and Availability

Size Price Availability Quantity
1mg USD 95 Ready to ship
5mg USD 250 Ready to Ship
10mg USD 450 Ready to Ship
25mg USD 950 Ready to Ship
50mg USD 1650 Ready to Ship
100mg USD 2650 Ready to Ship
Bulk inquiry

Related CAS #: 587879-32-1 (free base)   587879-54-7 (mesylate)   587879-57-0 (HCl)    

Synonym: KM-003; KM 003; KM003; P552-02; P552 02; P55202; P 55202; P-55202; P552-02 mesylate; PS 552-02; 552-02

IUPAC/Chemical Name: 3,5-diamino-6-chloro-N-(N-(4-(4-(2,3-dihydroxypropoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

InChi Key: NTRKMGDUWYBLMS-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)

SMILES Code: O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCCCCC2=CC=C(OCC(O)CO)C=C2)=N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 587879-32-1(552-02 Free base) 587879-54-7(552-02 Sulfite)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 451.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Coote KJ, Paisley D, Czarnecki S, Tweed M, Watson H, Young A, Sugar R, Vyas M, Smith NJ, Baettig U, Groot-Kormelink PJ, Gosling M, Lock R, Ethell B, Williams G, Schumacher A, Harris J, Abraham WM, Sabater J, Poll CT, Faller T, Collingwood SP, Danahay H. NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia. Br J Pharmacol. 2015 Jun;172(11):2814-26. doi: 10.1111/bph.13075. Epub 2015 Apr 23. PMID: 25573195; PMCID: PMC4439877.


2: Blé FX, Cannet C, Collingwood S, Danahay H, Beckmann N. ENaC-mediated effects assessed by MRI in a rat model of hypertonic saline-induced lung hydration. Br J Pharmacol. 2010 Jun;160(4):1008-15. doi: 10.1111/j.1476-5381.2010.00747.x. PMID: 20590595; PMCID: PMC2936005.


3: Hirsh AJ, Molino BF, Zhang J, Astakhova N, Geiss WB, Sargent BJ, Swenson BD, Usyatinsky A, Wyle MJ, Boucher RC, Smith RT, Zamurs A, Johnson MR. Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem. 2006 Jul 13;49(14):4098-115. doi: 10.1021/jm051134w. PMID: 16821771.