WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526426
CAS#: 107534-96-3
Description: Tebuconazole is a triazole fungicide used agriculturally to treat plant pathogenic fungi. Though the U.S. Food and Drug Administration considers this fungicide to be safe for humans, it may still pose a risk. It is listed as a possible carcinogen in the United States Environmental Protection Agency Office of Pesticide Programs carcinogen list with a rating of C (possible carcinogen). Its acute toxicity is moderate. According to the World Health Organization toxicity classification, it is listed as III, which means slightly hazardous.
Hodoodo Cat#: H526426
Name: Tebuconazole
CAS#: 107534-96-3
Chemical Formula: C16H22ClN3O
Exact Mass: 307.15
Molecular Weight: 307.822
Elemental Analysis: C, 62.43; H, 7.20; Cl, 11.52; N, 13.65; O, 5.20
Synonym: Tebuconazole
IUPAC/Chemical Name: (RS)- 1-(4-Chlorophenyl)- 4,4-dimethyl-3-(1H, 1,2,4-triazol-1-ylmethyl)pentan- 3-ol
InChi Key: PXMNMQRDXWABCY-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H22ClN3O/c1-15(2,3)16(21,10-20-12-18-11-19-20)9-8-13-4-6-14(17)7-5-13/h4-7,11-12,21H,8-10H2,1-3H3
SMILES Code: CC(C)(C)C(O)(CN1N=CN=C1)CCC2=CC=C(Cl)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Due to the potential for endocrine-disrupting effects, tebuconazole was assessed by the Swedish Chemicals Agency[3] as being potentially removed from the market by EU regulation 1107/2009
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The following data is based on the product molecular weight 307.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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2: You X, Li Y, Wang X, Xu J, Zheng X, Sui C. Residue analysis and risk assessment of tebuconazole in jujube (Ziziphus jujuba Mill). Biomed Chromatogr. 2016 Dec 13. doi: 10.1002/bmc.3917. [Epub ahead of print] PubMed PMID: 27957735.
3: Tyndall JD, Sabherwal M, Sagatova AA, Keniya MV, Negroni J, Wilson RK, Woods MA, Tietjen K, Monk BC. Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals. PLoS One. 2016 Dec 1;11(12):e0167485. doi: 10.1371/journal.pone.0167485. PubMed PMID: 27907120; PubMed Central PMCID: PMC5132298.
4: Roszko MŁ, Kamińska M, Szymczyk K, Jędrzejczak R. Levels of Selected Persistent Organic Pollutants (PCB, PBDE) and Pesticides in Honey Bee Pollen Sampled in Poland. PLoS One. 2016 Dec 1;11(12):e0167487. doi: 10.1371/journal.pone.0167487. PubMed PMID: 27907097; PubMed Central PMCID: PMC5132244.
5: Kim JO, Shin JH, Gumilang A, Chung K, Choi KY, Kim KS. Effectiveness of Different Classes of Fungicides on Botrytis cinerea Causing Gray Mold on Fruit and Vegetables. Plant Pathol J. 2016 Dec;32(6):570-574. PubMed PMID: 27904464; PubMed Central PMCID: PMC5117866.
6: Huete-Soto A, Masís-Mora M, Lizano-Fallas V, Chin-Pampillo JS, Carazo-Rojas E, Rodríguez-Rodríguez CE. Simultaneous removal of structurally different pesticides in a biomixture: Detoxification and effect of oxytetracycline. Chemosphere. 2017 Feb;169:558-567. doi: 10.1016/j.chemosphere.2016.11.106. PubMed PMID: 27898329.
7: Li H, Zhang M, Vervoort J, Rietjens IM, van Ravenzwaay B, Louisse J. Use of physiologically based kinetic modeling-facilitated reverse dosimetry of in vitro toxicity data for prediction of in vivo developmental toxicity of tebuconazole in rats. Toxicol Lett. 2016 Nov 24. pii: S0378-4274(16)33317-3. doi: 10.1016/j.toxlet.2016.11.017. [Epub ahead of print] PubMed PMID: 27890808.
8: Yang L, Yang D, Yan X, Cui L, Wang Z, Yuan H. The role of gibberellins in improving the resistance of tebuconazole-coated maize seeds to chilling stress by microencapsulation. Sci Rep. 2016 Nov 7;6:35447. doi: 10.1038/srep35447. PubMed PMID: 27819337; PubMed Central PMCID: PMC5098164.
9: Badawi N, Rosenbom AE, Jensen AM, Sørensen SR. Degradation and sorption of the fungicide tebuconazole in soils from golf greens. Environ Pollut. 2016 Dec;219:368-378. doi: 10.1016/j.envpol.2016.10.045. PubMed PMID: 27814554.
10: Meletiadis J, Leth Mortensen K, Verweij PE, Mouton JW, Arendrup MC. Spectrophotometric reading of EUCAST antifungal susceptibility testing of Aspergillus fumigatus. Clin Microbiol Infect. 2016 Oct 25. pii: S1198-743X(16)30506-7. doi: 10.1016/j.cmi.2016.10.017. [Epub ahead of print] PubMed PMID: 27793736.
11: Regueiro J, Negreira N, Berntssen MH. Ion-Mobility-Derived Collision Cross Section as an Additional Identification Point for Multiresidue Screening of Pesticides in Fish Feed. Anal Chem. 2016 Nov 15;88(22):11169-11177. PubMed PMID: 27779869.
12: Baćmaga M, Wyszkowska J, Kucharski J. The effect of the Falcon 460 EC fungicide on soil microbial communities, enzyme activities and plant growth. Ecotoxicology. 2016 Oct;25(8):1575-1587. PubMed PMID: 27631526.
13: Mateo R, Petkov N, Lopez-Antia A, Rodríguez-Estival J, Green AJ. Risk assessment of lead poisoning and pesticide exposure in the declining population of red-breasted goose (Branta ruficollis) wintering in Eastern Europe. Environ Res. 2016 Nov;151:359-367. doi: 10.1016/j.envres.2016.07.017. PubMed PMID: 27529395.
14: Wei Q, Song Z, Nie J, Xia H, Chen F, Li Z, Lee M. Tablet-effervescence-assisted dissolved carbon flotation for the extraction of four triazole fungicides in water by gas chromatography with mass spectrometry. J Sep Sci. 2016 Dec;39(23):4603-4609. doi: 10.1002/jssc.201600619. PubMed PMID: 27734583.
15: Fu Y, Yang T, Zhao J, Zhang L, Chen R, Wu Y. Determination of eight pesticides in Lycium barbarum by LC-MS/MS and dietary risk assessment. Food Chem. 2017 Mar 1;218:192-198. doi: 10.1016/j.foodchem.2016.09.014. PubMed PMID: 27719897.
16: Hellin P, Scauflaire J, Van Hese V, Munaut F, Legrève A. Sensitivity of Fusarium culmorum to triazoles: impact of trichothecene chemotypes, oxidative stress response and genetic diversity. Pest Manag Sci. 2016 Oct 3. doi: 10.1002/ps.4450. [Epub ahead of print] PubMed PMID: 27696645.
17: Díaz-Blancas V, Medina DI, Padilla-Ortega E, Bortolini-Zavala R, Olvera-Romero M, Luna-Bárcenas G. Nanoemulsion Formulations of Fungicide Tebuconazole for Agricultural Applications. Molecules. 2016 Sep 26;21(10). pii: E1271. PubMed PMID: 27681721.
18: Buszewicz G, Rejczak T, Tuzimski T, Teresiński G, Pieniążek D. Comparison of SPE/d-SPE and QuEChERS-Based Extraction Procedures in Terms of Fungicide Residue Analysis in Wine Samples by HPLC-DAD and LC-QqQ-MS. J AOAC Int. 2016 Sep 14. [Epub ahead of print] PubMed PMID: 27634101.
19: Su H, Lin Y, Wang Z, Wong YL, Chen X, Chan TW. Magnetic metal-organic framework-titanium dioxide nanocomposite as adsorbent in the magnetic solid-phase extraction of fungicides from environmental water samples. J Chromatogr A. 2016 Sep 30;1466:21-8. doi: 10.1016/j.chroma.2016.08.066. PubMed PMID: 27592609.
20: Urbanczyk MM, Bollmann UE, Bester K. Partition of biocides between water and inorganic phases of renders with organic binder. Sci Total Environ. 2016 Dec 15;573:639-644. doi: 10.1016/j.scitotenv.2016.08.129. PubMed PMID: 27585432.
