WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H329510
CAS#: 1496510-51-0
Description: Relacorilant is discontinued.
Hodoodo Cat#: H329510
Name: Relacorilant
CAS#: 1496510-51-0
Chemical Formula: C27H22F4N6O3S
Exact Mass: 586.14
Molecular Weight: 586.566
Elemental Analysis: C, 55.29; H, 3.78; F, 12.96; N, 14.33; O, 8.18; S, 5.47
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Relacorilant, CORT125134; CORT-125134; CORT 125134.
IUPAC/Chemical Name: [(4aR)-1-(4-fluorophenyl)-6-(1-methyl-1H-pyrazole-4-sulfonyl)-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)pyridin- 2-yl]methanone
InChi Key: WANIDIGFXJFFEL-SANMLTNESA-N
InChi Code: InChI=1S/C27H22F4N6O3S/c1-35-15-22(14-33-35)41(39,40)36-9-7-18-11-24-17(13-34-37(24)21-4-2-20(28)3-5-21)12-26(18,16-36)25(38)23-10-19(6-8-32-23)27(29,30)31/h2-6,8,10-11,13-15H,7,9,12,16H2,1H3/t26-/m0/s1
SMILES Code: O=C([C@]12CC3=C(N(C4=CC=C(F)C=C4)N=C3)C=C1CCN(S(=O)(C5=CN(C)N=C5)=O)C2)C6=NC=CC(C(F)(F)F)=C6
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 586.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J,
Phillips T, Swift D, Eaton E. Identification of the Clinical Candidate
(R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexah
ydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methano
ne (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem.
2017 Apr 17. doi: 10.1021/acs.jmedchem.7b00162. [Epub ahead of print] PubMed
PMID: 28368581.
2: Bali U, Phillips T, Hunt H, Unitt J. FKBP5 mRNA Expression Is a Biomarker for
GR Antagonism. J Clin Endocrinol Metab. 2016 Nov;101(11):4305-4312. Epub 2016 Jul
26. PubMed PMID: 27459525.
3: Stringer-Reasor EM, Baker GM, Skor MN, Kocherginsky M, Lengyel E, Fleming GF,
Conzen SD. Glucocorticoid receptor activation inhibits chemotherapy-induced cell
death in high-grade serous ovarian carcinoma. Gynecol Oncol. 2015
Sep;138(3):656-62. doi: 10.1016/j.ygyno.2015.06.033. Epub 2015 Jun 24. PubMed
PMID: 26115975; PubMed Central PMCID: PMC4556542.