WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526482
CAS#: 43121-43-3
Description: Triadimefon is an azole fungicide.
Hodoodo Cat#: H526482
Name: Triadimefon
CAS#: 43121-43-3
Chemical Formula: C14H16ClN3O2
Exact Mass: 293.09
Molecular Weight: 293.751
Elemental Analysis: C, 57.24; H, 5.49; Cl, 12.07; N, 14.30; O, 10.89
Synonym: Triadimefon
IUPAC/Chemical Name: 1-(4-Chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butanone
InChi Key: WURBVZBTWMNKQT-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H16ClN3O2/c1-14(2,3)12(19)13(18-9-16-8-17-18)20-11-6-4-10(15)5-7-11/h4-9,13H,1-3H3
SMILES Code: CC(C)(C)C(C(OC1=CC=C(Cl)C=C1)N2N=CN=C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 293.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Li J, Chang J, Li W, Guo B, Li J, Wang H. Disruption of sex-hormone levels and steroidogenic-related gene expression on Mongolia Racerunner (Eremias argus) after exposure to triadimefon and its enantiomers. Chemosphere. 2016 Dec 22;171:554-563. doi: 10.1016/j.chemosphere.2016.12.096. [Epub ahead of print] PubMed PMID: 28039834.
2: Xu P, Huang L. Stereoselective bioaccumulation, transformation, and toxicity of triadimefon in Scenedesmus obliquus. Chirality. 2016 Dec 23. doi: 10.1002/chir.22671. [Epub ahead of print] PubMed PMID: 28009445.
3: Kong Z, Li M, An J, Chen J, Bao Y, Francis F, Dai X. The fungicide triadimefon affects beer flavor and composition by influencing Saccharomyces cerevisiae metabolism. Sci Rep. 2016 Sep 15;6:33552. doi: 10.1038/srep33552. PubMed PMID: 27629523; PubMed Central PMCID: PMC5024320.
4: Cao C, Wang Q, Jiao F, Zhu G. Impact of co-exposure with butachlor and triadimefon on thyroid endocrine system in larval zebrafish. Exp Toxicol Pathol. 2016 Sep;68(8):463-9. doi: 10.1016/j.etp.2016.07.004. PubMed PMID: 27480594.
5: Paul Friedman K, Papineni S, Marty MS, Yi KD, Goetz AK, Rasoulpour RJ, Kwiatkowski P, Wolf DC, Blacker AM, Peffer RC. A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study. Crit Rev Toxicol. 2016 Oct;46(9):785-833. doi: 10.1080/10408444.2016.1193722. PubMed PMID: 27347635; PubMed Central PMCID: PMC5044773.
6: Li M, Li S, Yao T, Zhao R, Wang Q, Zhu G. Waterborne exposure to triadimefon causes thyroid endocrine disruption and developmental delay in Xenopus laevis tadpoles. Aquat Toxicol. 2016 Aug;177:190-7. doi: 10.1016/j.aquatox.2016.05.018. PubMed PMID: 27289584.
7: Hsu LS, Chiou BH, Hsu TW, Wang CC, Chen SC. The regulation of transcriptome responses in zebrafish embryo exposure to triadimefon. Environ Toxicol. 2017 Jan;32(1):217-226. doi: 10.1002/tox.22227. PubMed PMID: 26790661.
8: Pallocca G, Grinberg M, Henry M, Frickey T, Hengstler JG, Waldmann T, Sachinidis A, Rahnenführer J, Leist M. Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80. doi: 10.1007/s00204-015-1658-7. PubMed PMID: 26705709; PubMed Central PMCID: PMC4710658.
9: Yao Z, Li X, Miao Y, Lin M, Xu M, Wang Q, Zhang H. Simultaneous enantioselective determination of triadimefon and its metabolite triadimenol in edible vegetable oil by gel permeation chromatography and ultraperformance convergence chromatography/tandem mass spectrometry. Anal Bioanal Chem. 2015 Nov;407(29):8849-59. doi: 10.1007/s00216-015-9046-y. PubMed PMID: 26416018.