NI-42
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H406993

CAS#: 1884640-99-6

Description: NI-42 is a potent and selective BRPF1 in inhibitor with BRPF1 IC50 = 7.9 nM; LE: 0.45; LLE: 5.6. NI-42 is suitable for cellular and in vivo studies to explore the fundamental biology of these proteins. The BRPF (bromodomain and PHD finger-containing) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Evaluation of the BRPF family as a potential drug target is at an early stage although there is an emerging understanding of a role in acute myeloid leukemia (AML).

Chemical Structure

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NI-42
CAS# 1884640-99-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H406993
Name: NI-42
CAS#: 1884640-99-6
Chemical Formula: C18H15N3O3S
Exact Mass: 353.08
Molecular Weight: 353.396
Elemental Analysis: C, 61.18; H, 4.28; N, 11.89; O, 13.58; S, 9.07

Price and Availability

Size Price Availability Quantity
5mg USD 250 2 Weeks
10mg USD 450 2 Weeks
25mg USD 850 2 Weeks
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Synonym: NI-42; NI 42; NI42.

IUPAC/Chemical Name: 4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

InChi Key: BMVCSXFOQPYKKC-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H15N3O3S/c1-12-9-14-10-15(5-8-17(14)21(2)18(12)22)20-25(23,24)16-6-3-13(11-19)4-7-16/h3-10,20H,1-2H3

SMILES Code: O=S(C1=CC=C(C#N)C=C1)(NC2=CC(C=C(C)C(N3C)=O)=C3C=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 353.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies
Niall IgoeElliott D. BayleOleg FedorovCynthia TallantPavel SavitskyCatherine RogersDafydd R. OwenGauri DebTim C. P. SomervailleDavid M. AndrewsNeil JonesAnne CheastyHamish RyderPaul E. BrennanSusanne MüllerStefan Knappand Paul V. Fish
Publication Date (Web): January 9, 2017 (Article)
DOI: 10.1021/acs.jmedchem.6b01583