WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530017
CAS#: 287405-51-0
Description: Apratastat, also known as TMI-005 and XMT-1191, is a matrix metalloproteinase/tumour necrosis factor-α convertase inhibitor.
Hodoodo Cat#: H530017
Name: Apratastat
CAS#: 287405-51-0
Chemical Formula: C17H22N2O6S2
Exact Mass: 414.09
Molecular Weight: 414.490
Elemental Analysis: C, 49.26; H, 5.35; N, 6.76; O, 23.16; S, 15.47
Synonym: TMI-005; TMI005; TMI 005; XMT-1191; XMT 1191; XMT1191. Apratastat.
IUPAC/Chemical Name: (3S)-N-Hydroxy-4-((4-((4-hydroxybut-2-ynyl)oxy)phenyl)sulfonyl)-2,2-dimethylthiomorpholine-3-carboxamide
InChi Key: MAVDNGWEBZTACC-HNNXBMFYSA-N
InChi Code: InChI=1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1
SMILES Code: O=C([C@@H]1N(S(=O)(C2=CC=C(OCC#CCO)C=C2)=O)CCSC1(C)C)NO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 414.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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6: Moss ML, Rasmussen FH. Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Anal Biochem. 2007 Jul 15;366(2):144-8. doi: 10.1016/j.ab.2007.04.043. Epub 2007 May 3. PMID: 17548045.
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