WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529603
CAS#: 868208-92-8
Description: Chinfloxacin is a quinolone antibiotic potentially for the treatment of bacterial infections.
Hodoodo Cat#: H529603
Name: Chinfloxacin
CAS#: 868208-92-8
Chemical Formula: C21H22F3N3O4
Exact Mass: 437.16
Molecular Weight: 437.410
Elemental Analysis: C, 57.66; H, 5.07; F, 13.03; N, 9.61; O, 14.63
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Synonym: IMB-031124; IMB031124; IMB 031124
IUPAC/Chemical Name: 1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChi Key: KNLARSZRTBDTIA-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H22F3N3O4/c22-14-6-12-16(27(11-3-4-11)8-13(18(12)28)20(29)30)19(31-21(23)24)17(14)26-7-10-2-1-5-25-15(10)9-26/h6,8,10-11,15,21,25H,1-5,7,9H2,(H,29,30)
SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N(C4)CC5C4CCCN5)=C3OC(F)F)C1=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 437.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Li GQ, Yuan M, Yang XY, Li CR, Hu XX, Zhang WX, Lou RH, Guo HY, You XW, Cen S, Jiang JD, You XF. In vitro antibacterial activity of chinfloxacin, a new fluoroquinolone antibiotic. Chemotherapy. 2012;58(3):175-84. doi: 10.1159/000337084. PubMed PMID: 22699239.
2: Li GQ, Bai XG, Li CR, Yang XY, Hu XX, Yuan M, Zhang WX, Lou RH, Guo HY, Jiang JD, You XF. In vivo antibacterial activity of chinfloxacin, a new fluoroquinolone antibiotic. J Antimicrob Chemother. 2012 Apr;67(4):955-61. doi: 10.1093/jac/dkr557. PubMed PMID: 22210757.
3: Zhang XM, Zhu ZH, Sun XL, Guo J, Zhao ZZ, Zhang Z. [Chinfloxacin hydrochloride inhibits HERG potassium channel at open state]. Yao Xue Xue Bao. 2010 Dec;45(12):1491-6. Chinese. PubMed PMID: 21351488.