WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529614
CAS#: 960210-99-5
Description: PM-060184 is a tubulin polymerisation inhibitor potentially for the treatment of solid tumours and breast cancer.
Hodoodo Cat#: H529614
Name: PM-060184
CAS#: 960210-99-5
Chemical Formula: C31H45N3O7
Exact Mass: 571.33
Molecular Weight: 571.710
Elemental Analysis: C, 65.13; H, 7.93; N, 7.35; O, 19.59
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Synonym: PM-060184; PM060184; PM 060184
IUPAC/Chemical Name: (S,1Z,6Z)-1-((S)-2-((S,2Z,4Z,6E)-8-((S)-5-methoxy-6-oxo-3,6-dihydro-2H-pyran-2-yl)-6-methylnona-2,4,6-trienamido)-3,3-dimethylbutanamido)octa-1,6-dien-4-yl carbamate
InChi Key: IEKGSKLKBICCHQ-BDOJOPHNSA-N
InChi Code: InChI=1S/C31H45N3O7/c1-8-9-14-23(40-30(32)38)15-12-19-33-28(36)27(31(4,5)6)34-26(35)16-11-10-13-21(2)20-22(3)24-17-18-25(39-7)29(37)41-24/h8-13,16,18-20,22-24,27H,14-15,17H2,1-7H3,(H2,32,38)(H,33,36)(H,34,35)/b9-8-,13-10-,16-11-,19-12-,21-20+/t22-,23-,24-,27+/m0/s1
SMILES Code: C[C@H]([C@@H]1CC=C(OC)C(O1)=O)/C=C(C)/C=C\C=C/C(N[C@H](C(N/C=C\C[C@@H](OC(N)=O)C/C=C\C)=O)C(C)(C)C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 571.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Martínez-Díez M, Guillén-Navarro MJ, Pera B, Bouchet BP, Martínez-Leal JF, Barasoain I, Cuevas C, Andreu JM, García-Fernández LF, Díaz JF, Avilés P, Galmarini CM. PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors. Biochem Pharmacol. 2014 Apr 1;88(3):291-302. doi: 10.1016/j.bcp.2014.01.026. PubMed PMID: 24486569.
2: Pera B, Barasoain I, Pantazopoulou A, Canales A, Matesanz R, Rodriguez-Salarichs J, García-Fernandez LF, Moneo V, Jiménez-Barbero J, Galmarini CM, Cuevas C, Peñalva MA, Díaz JF, Andreu JM. New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism. ACS Chem Biol. 2013 Sep 20;8(9):2084-94. doi: 10.1021/cb400461j. PubMed PMID: 23859655.
3: Martín MJ, Coello L, Fernández R, Reyes F, Rodríguez A, Murcia C, Garranzo M, Mateo C, Sánchez-Sancho F, Bueno S, de Eguilior C, Francesch A, Munt S, Cuevas C. Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds. J Am Chem Soc. 2013 Jul 10;135(27):10164-71. doi: 10.1021/ja404578u. PubMed PMID: 23750450.
4: Prota AE, Bargsten K, Diaz JF, Marsh M, Cuevas C, Liniger M, Neuhaus C, Andreu JM, Altmann KH, Steinmetz MO. A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21. doi: 10.1073/pnas.1408124111. PubMed PMID: 25114240; PubMed Central PMCID: PMC4183314.
5: Field JJ, Waight AB, Senter PD. A previously undescribed tubulin binder. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13684-5. doi: 10.1073/pnas.1414572111. PubMed PMID: 25187564; PubMed Central PMCID: PMC4183339.