WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529615
CAS#: 126100-97-8
Description: Dimiracetam is a NMDA-receptor antagonist potentially for the treatment of neuropathic pain
Hodoodo Cat#: H529615
Name: Dimiracetam
CAS#: 126100-97-8
Chemical Formula: C6H8N2O2
Exact Mass: 140.06
Molecular Weight: 140.140
Elemental Analysis: C, 51.42; H, 5.75; N, 19.99; O, 22.83
This product is not in stock, which may be available by custom synthesis.
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Synonym: NT-11624; BND-11624; ISF-4185; NT11624; BND11624; ISF4185; NT 11624; BND 11624; ISF 4185
IUPAC/Chemical Name: tetrahydro-5H-pyrrolo[1,2-a]imidazole-2,5(3H)-dione
InChi Key: XTXXOHPHLNROBN-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H8N2O2/c9-5-3-8-4(7-5)1-2-6(8)10/h4H,1-3H2,(H,7,9)
SMILES Code: O=C1NC(CCC2=O)N2C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 140.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Di Cesare Mannelli L, Maresca M, Farina C, Scherz MW, Ghelardini C. A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam. Neurotoxicology. 2015 Sep;50:101-7. doi: 10.1016/j.neuro.2015.08.002. PubMed PMID: 26254739.
2: Fariello RG, Ghelardini C, Di Cesare Mannelli L, Bonanno G, Pittaluga A, Milanese M, Misiano P, Farina C. Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain. Neuropharmacology. 2014 Jun;81:85-94. doi: 10.1016/j.neuropharm.2014.01.029. PubMed PMID: 24486381.
3: Farina C, Gagliardi S, Ghelardini C, Martinelli M, Norcini M, Parini C, Petrillo P, Ronzoni S. Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain. Bioorg Med Chem. 2008 Mar 15;16(6):3224-32. doi: 10.1016/j.bmc.2007.12.015. PubMed PMID: 18171618.
4: Torchio L, Lombardi F, Visconti M, Doyle E. Determination of the polar drug dimiracetam in human plasma and serum by column-switching high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Apr 7;666(1):169-77. PubMed PMID: 7655615.
5: Pinza M, Farina C, Cerri A, Pfeiffer U, Riccaboni MT, Banfi S, Biagetti R, Pozzi O, Magnani M, Dorigotti L. Synthesis and pharmacological activity of a series of dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H,6H)-diones, a novel class of potent cognition enhancers. J Med Chem. 1993 Dec 24;36(26):4214-20. PubMed PMID: 8277504.
