BHF-177

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H531570

CAS#: 917896-43-6

Description: BHF-177 is a positive allosteric modulator at the GABAB receptor. It was shown to reduce self-administration of nicotine in animal studies.


Chemical Structure

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BHF-177
CAS# 917896-43-6

Theoretical Analysis

Hodoodo Cat#: H531570
Name: BHF-177
CAS#: 917896-43-6
Chemical Formula: C19H20F3N3
Exact Mass: 347.16
Molecular Weight: 347.390
Elemental Analysis: C, 65.69; H, 5.80; F, 16.41; N, 12.10

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BHF-177; BHF 177; BHF177.

IUPAC/Chemical Name: N-[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]-2-methyl-5-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine

InChi Key: ADHZHPOKTRHZGT-DXCKQFNASA-N

InChi Code: InChI=1S/C19H20F3N3/c1-11-23-10-16(13-4-6-15(7-5-13)19(20,21)22)18(24-11)25-17-9-12-2-3-14(17)8-12/h4-7,10,12,14,17H,2-3,8-9H2,1H3,(H,23,24,25)/t12-,14+,17+/m0/s1

SMILES Code: FC(C1=CC=C(C2=CN=C(C)N=C2N[C@H]3[C@](C4)([H])CC[C@]4([H])C3)C=C1)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 347.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li X, Kaczanowska K, Finn MG, Markou A, Risbrough VB. The GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats. Neuropharmacology. 2015 Oct;97:357-64. doi: 10.1016/j.neuropharm.2015.05.001. PubMed PMID: 26002628; PubMed Central PMCID: PMC4537349.

2: Li X, Risbrough VB, Cates-Gatto C, Kaczanowska K, Finn MG, Roberts AJ, Markou A. Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. Neuropharmacology. 2013 Jul;70:156-67. doi: 10.1016/j.neuropharm.2013.01.018. PubMed PMID: 23376712; PubMed Central PMCID: PMC3644349.

3: Orrù A, Fujani D, Cassina C, Conti M, Di Clemente A, Cervo L. Operant, oral alcoholic beer self-administration by C57BL/6J mice: effect of BHF177, a positive allosteric modulator of GABA(B) receptors. Psychopharmacology (Berl). 2012 Aug;222(4):685-700. doi: 10.1007/s00213-012-2672-6. PubMed PMID: 22411427.

4: Vlachou S, Guery S, Froestl W, Banerjee D, Benedict J, Finn MG, Markou A. Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats. Psychopharmacology (Berl). 2011 May;215(1):117-28. doi: 10.1007/s00213-010-2119-x. PubMed PMID: 21181127; PubMed Central PMCID: PMC3072487.