WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H531660
CAS#: 883050-24-6
Description: CCG-50014 is a potent small molecule inhibitor of regulator of G-protein signaling protein 4 (RGS4).
Hodoodo Cat#: H531660
Name: CCG-50014
CAS#: 883050-24-6
Chemical Formula: C16H13FN2O2S
Exact Mass: 316.07
Molecular Weight: 316.350
Elemental Analysis: C, 60.75; H, 4.14; F, 6.01; N, 8.86; O, 10.11; S, 10.13
Synonym: CCG-50014; CCG 50014; CCG50014.
IUPAC/Chemical Name: 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
InChi Key: QUIIIYITNGOFEI-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
SMILES Code: O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 316.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yoon SY, Woo J, Park JO, Choi EJ, Shin HS, Roh DH, Kim KS. Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test. Anesth Analg. 2015 Mar;120(3):671-7. doi: 10.1213/ANE.0000000000000607. PubMed PMID: 25695583.
2: Vashisth H, Storaska AJ, Neubig RR, Brooks CL 3rd. Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. ACS Chem Biol. 2013 Dec 20;8(12):2778-84. doi: 10.1021/cb400568g. PubMed PMID: 24093330; PubMed Central PMCID: PMC3876963.
3: Blazer LL, Zhang H, Casey EM, Husbands SM, Neubig RR. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 2011 Apr 19;50(15):3181-92. doi: 10.1021/bi1019622. PubMed PMID: 21329361; PubMed Central PMCID: PMC3090679.