WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H531754
CAS#: 37151-17-0
Description: CV-1674 induces selective coronary vasodilation with less depression on cardiohemodynamics.
Hodoodo Cat#: H531754
Name: CV-1674
CAS#: 37151-17-0
Chemical Formula: C17H19N5O5
Exact Mass: 373.14
Molecular Weight: 373.370
Elemental Analysis: C, 54.69; H, 5.13; N, 18.76; O, 21.43
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Synonym: CV-1674; CV 1674; CV1674; NSC 310669.
IUPAC/Chemical Name: (2R,3R,4S,5R)-2-(6-amino-2-(4-methoxyphenyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChi Key: VKSRAKNPXOTFAX-CNEMSGBDSA-N
InChi Code: InChI=1S/C17H19N5O5/c1-26-9-4-2-8(3-5-9)15-20-14(18)11-16(21-15)22(7-19-11)17-13(25)12(24)10(6-23)27-17/h2-5,7,10,12-13,17,23-25H,6H2,1H3,(H2,18,20,21)/t10-,12-,13-,17-/m1/s1
SMILES Code: O[C@H]1[C@H](N2C=NC3=C(N)N=C(C4=CC=C(OC)C=C4)N=C23)O[C@H](CO)[C@H]1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 373.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Hirata M, Kawazoe K, Tanabe M, Kikuchi K. Effects of a 2-substituted adenosine derivative, 2-(p-methoxyphenyl)-adenosine (CV-1674) on coronary and cardiohemodynamics, and myocardial energetics. Jpn J Pharmacol. 1977 Oct;27(5):689-700. PubMed PMID: 592558.
2: Singh YN, Dryden WF, Chen H. The inhibitory effects of some adenosine analogues on transmitter release at the mammalian neuromuscular junction. Can J Physiol Pharmacol. 1986 Nov;64(11):1446-50. PubMed PMID: 3024786.
3: Paton DM. Presynaptic inhibition of neurotransmission in rat vas deferens by 2-(p-methoxyphenyl) adenosine, ethyl adenosine-5'-carboxylate and N-cyclopropyl adenosine-5'-carboxamide. J Pharm Pharmacol. 1980 Feb;32(2):133-5. PubMed PMID: 6103035.
4: van der Ploeg I, Ahlberg S, Parkinson FE, Olsson RA, Fredholm BB. Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists. Naunyn Schmiedebergs Arch Pharmacol. 1996 Feb;353(3):250-60. PubMed PMID: 8692279.