WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H531763
CAS#: 202578-52-7
Description: DMP696 is a non-peptidergic CRF1 receptor antagonist.
Hodoodo Cat#: H531763
Name: DMP696
CAS#: 202578-52-7
Chemical Formula: C18H21Cl2N5O2
Exact Mass: 409.11
Molecular Weight: 410.300
Elemental Analysis: C, 52.69; H, 5.16; Cl, 17.28; N, 17.07; O, 7.80
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Synonym: DMP696; DMP 696; DMP-696.
IUPAC/Chemical Name: 8-(2,4-dichlorophenyl)-N-(1,3-dimethoxypropan-2-yl)-2,7-dimethylpyrazolo[5,1-f][1,3,5]triazin-4-amine
InChi Key: MDWRPTOUDPFXKK-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H21Cl2N5O2/c1-10-16(14-6-5-12(19)7-15(14)20)17-21-11(2)22-18(25(17)24-10)23-13(8-26-3)9-27-4/h5-7,13H,8-9H2,1-4H3,(H,21,22,23)
SMILES Code: CC1=NN2C(NC(COC)COC)=NC(C)=NC2=C1C3=CC=C(Cl)C=C3Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 410.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Sullivan GM, Parsey RV, Kumar JS, Arango V, Kassir SA, Huang YY, Simpson NR, Van Heertum RL, Mann JJ. PET Imaging of CRF1 with [11C]R121920 and [11C]DMP696: is the target of sufficient density? Nucl Med Biol. 2007 May;34(4):353-61. PubMed PMID: 17499724; PubMed Central PMCID: PMC1933490.
2: Li YW, Fitzgerald L, Wong H, Lelas S, Zhang G, Lindner MD, Wallace T, McElroy J, Lodge NJ, Gilligan P, Zaczek R. The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists. CNS Drug Rev. 2005 Spring;11(1):21-52. Review. PubMed PMID: 15867951.
3: Li YW, Hill G, Wong H, Kelly N, Ward K, Pierdomenico M, Ren S, Gilligan P, Grossman S, Trainor G, Taub R, McElroy J, Zazcek R. Receptor occupancy of nonpeptide corticotropin-releasing factor 1 antagonist DMP696: correlation with drug exposure and anxiolytic efficacy. J Pharmacol Exp Ther. 2003 Apr;305(1):86-96. PubMed PMID: 12649356.
4: Lelas S, Zeller KL, Ward KA, McElroy JF. The anxiolytic CRF(1) antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats. Psychopharmacology (Berl). 2003 Apr;166(4):408-15. PubMed PMID: 12590355.
5: McElroy JF, Ward KA, Zeller KL, Jones KW, Gilligan PJ, He L, Lelas S. The CRF(1) receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats. Psychopharmacology (Berl). 2002 Dec;165(1):86-92. PubMed PMID: 12474122.
6: Maciag CM, Dent G, Gilligan P, He L, Dowling K, Ko T, Levine S, Smith MA. Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separation. Neuropsychopharmacology. 2002 May;26(5):574-82. PubMed PMID: 11927182.