WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H527602
CAS#: 886208-76-0 (free base)
Description: TT-301, also known as MW-189, is a cytokine inhibitor and glial cell inhibitor potentially for the treatment of traumatic brain injury.
Hodoodo Cat#: H527602
Name: TT-301
CAS#: 886208-76-0 (free base)
Chemical Formula: C23H21N7
Exact Mass: 395.19
Molecular Weight: 395.470
Elemental Analysis: C, 69.85; H, 5.35; N, 24.79
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Related CAS #: 1346545-21-8 (HCl) 886208-76-0 (free base)
Synonym: TT-301; TT 301; TT301; MW-189; MW 189 ;MW189
IUPAC/Chemical Name: 6-phenyl-4-(pyridin-4-yl)-3-(4-(pyrimidin-2-yl)piperazin-1-yl)pyridazine
InChi Key: ZPJGUEPHFXPAQF-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H21N7/c1-2-5-19(6-3-1)21-17-20(18-7-11-24-12-8-18)22(28-27-21)29-13-15-30(16-14-29)23-25-9-4-10-26-23/h1-12,17H,13-16H2
SMILES Code: C1(C2=CC(C3=CC=NC=C3)=C(N4CCN(C5=NC=CC=N5)CC4)N=N2)=CC=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 395.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: James ML, Wang H, Cantillana V, Lei B, Kernagis DN, Dawson HN, Klaman LD, Laskowitz DT. TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice. Anesthesiology. 2012 Jun;116(6):1299-311. doi: 10.1097/ALN.0b013e318253a02a. PubMed PMID: 22487803.